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- Statistical Genetics of Complex Diseases
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1. Population genetics considerations
- Prof. Nan Laird
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2. Gene-by-environment interaction: study designs and analytical methods
- Prof. L. Adrienne Cupples
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3. Analysis of SNP haplotypes
- Prof. Lyle Palmer
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4. Statistical issues in epidemiological studies of gene-environment interaction
- Dr. Peter Kraft
- Prof. Donna Spiegelman
- Molecular Epidemiology of Pulmonary Diseases
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5. Molecular epidemiology of lung cancer
- Prof. David Christiani
- Autoimmune Diffuse Connective Tissue Diseases
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7. Environmental scleroderma: the evidence for putative triggers
- Prof. Maureen Mayes
- Drug-Induced Disease
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8. Drug-induced lupus
- Prof. Evelyn Hess
- Archived Lectures *These may not cover the latest advances in the field
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9. Biomarkers of exposure
- Prof. Thomas Smith
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10. GIS and spatial statistics
- Prof. Louise Ryan
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11. Gene-by-environment interactions in COPD
- Prof. Edwin Silverman
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14. Indians, twins and scleroderma: genetic and genomic studies
- Prof. Frank Arnett
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15. Gene by environment interaction in asthma
- Prof. Scott Weiss
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16. Molecular epidemiology of lung cancer
- Prof. David Christiani
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18. Infectious environmental factors and systemic lupus erythematosus
- Prof. Judith James
Printable Handouts
Navigable Slide Index
- Intoduction
- Predisposition to lupus and scleroderma
- SLE and SSc
- Systemic sclerosis
- Environmental exposure and predisposition to SSc
- SSc environmental triggers
- Metabolic pathways of SSc triggers: solvents
- Solvent exposures and SSc risk
- Solvent exposures and SSc risk: CYP450 genes
- Solvent exposures x DME genes interaction
- Xenobiotic biotransformation pathways
- GSTT1 null/GSTM1 null x environment interaction
- Lupus prone U.S populations
- Lupus prone U.K populations
- African-Americans vs. European-Americans
- SLE in African-Americans
- Environment, genetic and behavioral factors
- Differential risk in African Americans
- Lupus risk - behavior
- Behavioral risk for SLE: smoking
- Modulation of smoking risk for SLE: DME genes?
- CYP450/GST x smoking interaction
- Environmental triggers foe lupus
- Prevalence gradient hypothesis
- Hypothesis: environmental triggers for lupus
- Prevalence gradient: etiologies
- Faber and Krieg research
- Differential environment x gene interaction
- Carolina lupus study
- UV x GSTM1 null interaction
- Future studies of differential lupus risk
- Environmental exposures and autoimmune disease
- Environmental triggers of SLE and SSc
- Cellular stress
- Cellular stress modulation
- Oxidant: antioxidant imbalance = oxidative stress
- Oxidative stress: animal and human data
- Oxidative stress: sequelae
- Oxidative stress: sequelae - cellular damage
- Silica: oxidative stress - inflammation
- Future research areas - OS and autoimmunity
- Future research areas
Topics Covered
- Epidemiology of lupus and scleroderma
- Racial and ethnic variation in disease susceptibility and expression
- Geographic variation
- Environmental triggers
- Hypothetical disease mechanisms of environmental triggers
- Future research directions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Fraser, P. (2007, October 1). Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/YGUX2149.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Patricia Fraser has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)
A selection of talks on Immunology
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