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- Architecture of the ribosome RNA-protein machine assembly
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2. Assembly of the 30S ribosomal subunit in vitro and in cells
- Prof. James Williamson
- Decoding and peptide bond formation
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3. How aminoacyl-tRNA synthetases translate the genetic code
- Dr. Stephen Cusack
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5. Elongation of protein synthesis: structural basis of the process of decoding
- Prof. Marina Rodnina
- Initiation of protein synthesis
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7. Factor independent initiation of protein synthesis by IRES RNAs
- Prof. Jeffrey Kieft
- Elongation and termination of protein synthesis
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8. Translocation: movement of tRNA and mRNA through the ribosome
- Prof. Harry Noller
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9. Recoding: getting more out of the message by shifting reading frame and redefining codon meaning
- Prof. John Atkins
- Prof. Raymond Gesteland
- Co-translational protein secretion
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10. Mechanism of translocon function: current insights and models
- Prof. Arnold Driessen
- How antibiotics target the ribosome
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12. Antibiotic inhibition of ribosome function
- Dr. Daniel Wilson
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13. Structure-based drug design targeting infectious disease
- Dr. Erin Duffy
- Archived Lectures *These may not cover the latest advances in the field
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15. Introduction to the ribosome
- Prof. Anders Liljas
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16. The structure of the intact ribosome and ribosomal subunit interactions
- Dr. Jamie H. Doudna Cate
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17. Structural insights into decoding of mRNA by the ribosome
- Prof. Venki Ramakrishnan
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18. Chemistry of peptide bond formation
- Prof. Rachel Green
Printable Handouts
Navigable Slide Index
- Introduction
- Acknowledgements
- Haloarcula marismortui is not a human pathogen
- Antibiotic - first definition
- Antibiotic - a broader definition
- Penicillin
- Paradox
- Antibiotic specificity problems
- Differences between ribosomes sensitivity
- Good news
- Bad news
- A complete 70S ribosome
- Large subuint
- A fifth active site at the large ribosimal subunit
- Structures of anti-ribosomal antibiotics
- Binding of puromycin in the large subunit
- Binding of anisomycin in the large subunit
- Binding of sparsomycin in the large subunit
- Binding of blasticidin in the large subunit
- Binding of tylosin in the large subunit
- Large/small subunit antibiotics
- Anisomycin binding to the A cleft
- Anisomycin cause conformation change
- Position of U2539
- Macrolide antibiotics
- Ribosome-antibiotic complexes
- Resistance to macrolide antibiotic
- Position 2099 identity is significant
- Azithromycin
- Differences in peptide length product
- Textbook explanation
Topics Covered
- Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics?
- Introduction to ribosome structure
- Antibiotic binding sites cluster in the ribosome
- The source of the species specificity of antibiotics that interact with the A-site cleft
- How macrolides interact with the ribosome
- The structural consequences of mutations that make ribosomes resistant to macrolides
- The toxicity of macrolides is not well understood
- 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Moore, P. (2008, May 15). The interaction of antibiotics with the large ribosomal subunit from Haloarcula marismortui [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/SEQG5769.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Moore has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The interaction of antibiotics with the large ribosomal subunit from Haloarcula marismortui
A selection of talks on Pharmaceutical Sciences
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