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1. Introduction
2. The 50S ribosomal subunit: a unique drug target
3. Why target the 50S ribosomal subunit?
4. Analysis of antibacterial market
5. Target markets
6. Drug resistance mechanisms (1)
7. Drug resistance mechanisms (2)
8. Intracellular vs. extracellular pathogens
9. Sequestration: MRSA abscess
10. Sequestration: biofilm development
11. Cell surfaces of Gram-positive/negative bacteria
12. How do antibiotics gain entry into cells?
13. Porins
14. Lack of uptake: streptogramin B
15. Self-promoted uptake: azithromycin
16. Drug modification: inactivation
17. Target modifications
18. Erm genes of bacteria and producer strains
19. 23S mutations conferring linezolid resistance
20. 23S mutations conferring macrolide resistance
21. Target modifications: rRNA operons
22. Target mutations: ribosomal proteins
23. Drug efflux
24. Major superfamilies of transport proteins
25. Illustration of drug efflux through transporters
26. General considerations

Topics Covered

• Why target the 50S ribosomal subunit?
• Analysis of antibacterial market
• Mechanisms of drug resistance
• Sequestration
• How do antibiotics gain entry into cells
• Porins
• Lack of uptake
• Self-promoted uptake drug modification
• Target modifications
• Drug efflux
• Major superfamilies of transport proteins

Links

Series:

• The Mechanisms of Ribosome Function

Categories:

• Biochemistry
• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Sutcliffe, J. (2008, May 15). Antibiotics that target the 50S ribosome subunit: resistance and other considerations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/CMET1434.
Export Citation (RIS)

Publication History

• Published on May 15, 2008

Financial Disclosures

• Dr. Joyce Sutcliffe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.