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Navigable Slide Index

1. Introduction
2. Recoding
3. Recoding features
4. Codon redefinition
5. Bacterial selenocysteine encoding
6. Selenocysteine encoding: 50S subunit interface
7. Mammalian selenocysteine: selenoprotein N
8. TMV RNA
9. MuLV gag stop codon redefinition
10. StopGo in foot-and-mouth disease virus
11. Frameshifting
12. Release factor 2 frameshift: plentiful RF2
13. Release factor 2 frameshift: RF2 limiting
14. E-site spacing at initiation
15. Conservation of RF2 shift site
16. ORF architecture
17. Human antizyme (+1) frameshift
18. Antizyme in polyamine regulation
19. Two models for Ty3 (+1) frameshifting
20. dnaX frameshift - DNA Pol subunits
21. "dnaX" transcriptional slippage
22. Beet western yellows virus: pseudoknot
23. Retroviruses - why recoding?
24. HIV gag - pol frameshifting
25. A frameshift signal: 4 kb 3' (1)
26. A frameshift signal: 4 kb 3' (2)
27. Discontiguity
28. T4 gene 60 bypassing
29. Ribosomal protein L9
30. tmRNA trans-translation
31. tmRNA-ribosome complex
32. Summary

Topics Covered

• Dynamic reprogramming of genetic readout
• 3 broad types
• Change in linearity, i.e. programmed ribosomal frame shifting
• Codon redefinition, i.e. commonly "stop codons" specifying an amino acid, a standard one or selenocysteine
• Discontiguity

Links

Series:

• The Mechanisms of Ribosome Function

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Atkins, J. and Gesteland, R. (2008, May 15). Recoding: getting more out of the message by shifting reading frame and redefining codon meaning [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/WZRW7329.
Export Citation (RIS)

Publication History

• Published on May 15, 2008

Financial Disclosures

• Prof. John Atkins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Raymond Gesteland has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.