Genetic and endosymbiont-based tools for mosquito and arbovirus control

Published on November 30, 2025   36 min

A selection of talks on Infectious Diseases

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Hi. My name's Dr. Perran Ross, and I'm a research fellow at the University of Melbourne in Australia. Today I'm going to be talking about some strategies that people are using at the moment to control mosquitoes and mosquito borne diseases around the world. To be able to control mosquitoes,
0:18
it's really important to have a good understanding of the mosquito life cycle and the places where they live and spread disease. Mosquitoes have both an aquatic and terrestrial stage. Mosquitoes will lay eggs either above the water or on the surface of the water, and then they can hatch into the aquatic phase. Mosquito larvae will feed on any source of nutrition that's in the water until they have enough food to complete their development. Once they reach the pupal stage, they'll sit there for a couple of days and then emerge into the adult mosquito. Adult mosquitoes are terrestrial. They will fly around and often they will try to seek a blood meal to be able to complete their life cycle. At most life stages, mosquitoes can actually pause their development and this is really an approach they use to be able to persist through cold and dry seasons.
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Mosquitoes are incredibly widespread around the world and they are very important disease vectors. If you look at all of the pathogens that mosquitoes will spread around the world, they will actually infect about 700 million people per year, and that can cause about one million deaths. That is mostly due to malaria, but there are many other diseases which mosquitoes spread, including things like dengue, Zika, chikungunya, and filarial worms. These pathogens cause a huge amount of disease which makes people very sick, and there's a huge economic cost of these diseases as well. The real problem with controlling mosquito-borne diseases is that many of these diseases do not have any effective vaccines, and if they do exist, they're not very widely available. The main way that we control mosquito-borne diseases is by controlling mosquito populations. This image here shows the distribution of the main vector of dengue fever (Aedes aegypti), and you can see that it is widespread around tropical and subtropical regions around the world; very widespread and there's a very large number of people that are at risk of these diseases.

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Genetic and endosymbiont-based tools for mosquito and arbovirus control

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