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1. Introduction
2. Talk introduction
3. Main aim
4. Methods
5. Experimental protocol
6. Steps of cardiac arrest production
7. Rats electrocardiogram
8. Changes in average heart rate
9. Rats electrocorticogram
10. Results
11. Short-term survival
12. Section reacted for horseradish peroxidase
13. High magnification of leaking vessels
14. Platelets and red cells blocking vessel
15. Horseradish peroxidase extravasations
16. HRP extravasationts into extracellular space
17. Platelets pathology in short-term survival animals
18. Platelets pathology in brain ischemia
19. C-terminal of amyloid precursor immunoreactivity
20. Immunoreactivity for beta-amyloid peptide
21. N-terminal of amyloid precursor immunoreactivity
22. Long-term survival
23. BBB permeability in animals with long-term survival
24. BBB changes in white matter of animals
25. Large platelet aggregate inside blood vessel
26. Two occluded vascular branches
27. Occluded vessel bifurcation
28. Amyloid precursor protein positive material (1)
29. Extra cellular amyloid precursor protein deposits
30. Amyloid precursor protein positive material (2)
31. Extra cellular amyloid precursor protein deposits
32. High magnification of vessel
33. Verifection of white matter in vicinity of vessels
34. Beta-amyloid peptide immunoreactivity
35. Beta-amyloid peptide plaque-like deposits
36. Evidence of beta-amyloid peptide circulatory origin
37. Experimental procedures - group 1
38. Experimental procedures - group 2
39. Observations (1)
40. Observations (2)
41. Observations (3)
42. Observations (4)
43. Observations (5)
44. Scheme of ischemic amyloid plaques development
45. Conclusion
46. Acknowledgements
47. References

Topics Covered

• Ischemic blood-brain barrier involved in Alzheimer's amyloid plaques development and full-blown Alzheimer's disease
• Brain ischemia starts Alzheimer's disease
• Association and risk factors for Alzheimer's disease
• Ischemic mechanisms in Alzheimer's disease in general

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Pluta, R. (2008, March 1). Ischemic blood-brain barrier and Alzheimer's amyloid plaques development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/774/.
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Publication History

• Published on March 1, 2008

Financial Disclosures

• Prof. Ryszard Pluta has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.