• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Question
3. Background (1)
4. Background (2)
5. Purpose
6. Determining in vivo brain-to-blood efflux transport
7. Clarifying molecular mechanism of BBB transport
8. Proving transport function of candidate transporter
9. Selected substrates
10. Why GABA ?
11. GABA result: in vivo transport activity
12. GABA result: transport mechanism
13. Why D- and L-Aspartic acid?
14. Asp result: in vivo transport activity
15. Asp result: transport mechanism
16. Why homovanillic acid (HVA)?
17. HVA result: in vivo transport activity
18. HVA result: transport mechanism
19. Why indoxyl sulfate (IS), uremic toxin?
20. Indoxyl sulfate result: in vivo transport activity
21. Indoxyl sulfate result: transport mechanism
22. Why 6-mercaptopurine and 6-thioguanine?
23. 6-MP and 6-TG result: in vivo transport activity (1)
24. 6-MP and 6-TG result: in vivo transport activity (2)
25. 6-MP and 6-TG result: transport mechanism
26. Why dehydroepiandrosteron sulfate (DHEAS)?
27. DHEAS result: in vivo transport activity
28. DHEAS result: transport mechanism
29. Why 24S-hydroxycholesterol?
30. 24S-hydroxycholesterol result
31. Conclusion
32. Illustrated conclusion
33. Perspective
34. Reference (1)
35. Reference (2)
36. Reference (3)
37. Reference (4)

Topics Covered

• The blood-brain barrier is not just a static wall, but "a cerebral clearance organ"
• The BBB multiple efflux transporters play a part in CNS detoxification by pumping out endogenous compounds from the brain
• Neurotransmitters
• Neuromodulators
• Metabolites of neurotransmitters
• Uremic toxins
• Cholesterol metabolites

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Terasaki, T. (2008, March 1). Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/OWEN4279.
Export Citation (RIS)

Publication History

• Published on March 1, 2008
• Archived on May 31, 2018

Financial Disclosures

• Prof. Tetsuya Terasaki has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.