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Printable Handouts
Navigable Slide Index
- Introduction
- Principles of ingestive peptides
- Obesity trends among U.S. adults
- Obesity as a disease
- Obesity has significant medical consequences
- Body weight regulation
- Diseases and conditions altering appetite
- Algebra of body weight
- New concepts on hormonal regulation
- Connection between the gut and the brain
- Peptides in brain and intestine
- A modern view of body weight control
- Blood to brain penetration
- Discovery of a mutation leading to obesity
- Discovering the leptin protein
- Leptin feedback loop
- Leptin levels are high in obesity
- Common form of obesity and leptin resistance
- Correlation of serum and CSF leptin levels
- Does "resistance" occur at the BBB?
- The BBB
- A classic experiment
- The CNS remains unstained
- Three modifications produce the BBB
- The BBB has a specific transport for leptin
- Correlation of serum and CSF leptin levels - human
- Correlation of serum and CSF leptin levels - mice
- Whole brain perfusion ratios in mice on a log scale
- Example of similar relations
- The system is saturated at high leptin serum levels
- Leptin signals adequate nutritional reserves
- What are our ancestral levels of leptin?
- Leptin levels can be measured in wild animals
- Lower leptin levels in animals living the wild
- Wild baboons in a more western lifestyle
- A wild baboon living in the jungle
- A wild baboon who feeds from garbage
- Levels of leptin in the two groups of baboons
- Medical diagnosis in wild baboons
- Leptin resistance and modern life style
- BBB leptin resistance in animal models of obesity
- Results from the obesity of maturity model
- 70% decrease in obese mice leptin transport rate
- Inhibition of leptin transport across the BBB
- BBB defects are reversible
- Evidence for regulation of the leptin transporter
- A substance in blood impairs leptin transport
- What factor is released in starvation and obesity?
- Triglycerides in blood inhibit leptin transport
- Triolein inhibits leptin transport
- Manipulating serum triglycerides by diet
- Gemfibrozil affect leptin transport
- Triglycerides inhibit labelled leptin transport in vitro
- Conclusion of triglycerides and leptin
- Why does leptin resistance develop in obesity?
- Circuitry during normal feeding and starvation
- Fat produces and acts upon many substances
- Other substances that affect feeding
- Broad categorical order in the digestive peptides
- Anorectic and orexigenic peptides
- Peptides produced by peripheral tissues and CNS
- Different categorization for substances
- Cost/benefit analysis in searching for food
- How ingestive peptides are inter-related?
- MSH inhibit feeding, Agouti stimulates feeding
- Agouti polymorphisms and POMC mutants
- Syndecans in feeding and fasting
- Ghrelin peptide
- Active form of ghrelin is octanoylated
- Leptin and ghrelin actions review
- Ghrelin is episodically released
- Ghrelin has high uptake across hippocampus BBB
- Ghrelin promotes LTP generation
- Ghrelin enhances learning and memory
- Conclusions
Topics Covered
- Ingestive peptides
- Transport across the blood-brain barrier
- Relation to obesity
- Control of transporter and implications for body weight control
- Ghrelin and its relation to the blood-brain barrier and body weight control
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Talk Citation
Banks, W. (2008, March 1). Ingestive peptides [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/DELD4279.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. William Banks has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.