• Structure of the blood-brain barrier
• 36 min
  1. The blood-brain barrier in Alzheimer’s disease

  • Dr. Anika Hartz
• 35 min
  2. Tanycytes allow a tight BBB in the median eminence

  • Prof. Esteban Rodriguez
  • Dr. Juan Luis Blazquez
  • Dr. Montserrat Guerra
• Nutrient transport
• 35 min
  3. Blood-brain barrier ion transport

  • Prof. Martha O'Donnell
• Peptides and proteins
• 37 min
  4. Ingestive peptides

  • Prof. William Banks
• 62 min
  5. Blood-brain barrier in health and disease

  • Prof. Thomas Davis
• Overcoming the blood-brain barrier obstacle
• 42 min
  6. Expression vs. function of ABC transporters at the blood-brain barrier

  • Prof. Jean-Michel Scherrmann
• 44 min
  7. The blood-brain barrier and CNS drug development

  • Dr. Danica Stanimirovic
• 34 min
  8. Transport and delivery of neurotrophic peptides and proteins across the BBB

  • Prof. Weihong Pan
• Diseases involving the blood-brain barrier
• 71 min
  9. Inflammation and immune cell entry to the central nervous system

  • Prof. Serge Rivest
• 42 min
  10. The blood-brain barrier in multiple sclerosis: a target for treatment?

  • Dr. Elga de Vries
• 24 min
  11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development

  • Prof. Ryszard Pluta
• Latest Developments in the Field
• 31 min
  12. MRI approaches for neurovascular imaging

  • Dr. Rick Dijkhuizen
• 33 min
  13. Brain-gut interactions in obesity 1

  • Prof. Weihong Pan
• 19 min
  14. Brain-gut interactions in obesity 2

  • Prof. Weihong Pan
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  15. Neurotrophins and the BBB

  • Prof. Weihong Pan
• 52 min
  16. Vasoactive peptides and the blood-brain barrier

  • Prof. Maria Deli
  • Prof. Bela Kis
• 42 min
  17. In vivo systems

  • Prof. Quentin Smith
• 46 min
  18. CNS-drug design

  • Prof. Quentin Smith
• 43 min
  19. Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

  • Prof. Tetsuya Terasaki
• 23 min
  20. Stroke and the BBB

  • Prof. Marilyn Cipolla
• 54 min
  21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings

  • Prof. Norman Saunders
• 57 min
  22. Barrier mechanisms in the developing brain: protection or vulnerability?

  • Prof. Norman Saunders
• 43 min
  23. In vitro models of the blood-brain barrier

  • Prof. Pierre-Olivier Couraud
• 41 min
  24. Glucose transport across the blood-brain barrier

  • Prof. Luc Leybaert
• 53 min
  25. The blood-brain barrier and brain tumors

  • Dr. Olaf van Tellingen
• 37 min
  26. Cellular composition of the blood-brain barrier

  • Prof. N. Joan Abbott
• 48 min
  27. Features of mammalian CNS barrier systems

  • Prof. Conrad Johanson

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Major transport interfaces in CNS
3. Features of mammalian CNS barrier systems
4. Topical presentation overview (1)
5. The choroid plexus system
6. Choroid plexus spurs brain development
7. Ramifying choroidal fronds and villi
8. Ultrastructure of choroidal epithelium
9. Schematic reconstruction of villus from EMs
10. Topical presentation overview (2)
11. Choroid plexus hemodynamics/hydrodynamics
12. CSF formation by choroid plexus
13. Transport mechanisms in choroidal epithelium
14. Pharmacologic modulation of CSF formation
15. Neuroendocrine regulation of CSF formation
16. Topical presentation overview (3)
17. Distribution of choroidal secretions to brain
18. Distribution of solutes from blood to brain
19. CSF-borne growth factors
20. A unique CSF transport pathway
21. Disruptions in CSF homeostasis
22. Topical presentation overview (4)
23. Why study BCSFB permeability and its breakdown
24. Quantifying the permeability of the BCSF barrier
25. Hypertension disruption of BCSF barrier
26. Hyperthermia damage to BCSF barrier
27. Ischemia disruption of the BCSF barrier
28. Topical presentation overview (5)
29. Kidney-like functions of choroid plexus
30. CSF turnover rate changes with aging
31. Choroid plexus dwindling in late stages of life
32. Loss of CSF sink action
33. Translational research opportunities
34. Conclusions

Topics Covered

• Choroid plexus
• Formation of CSF
• Permeability of blood
• CSF barrier vs. blood-brain barrier
• Choroidal secretion of peptides, growth factors and regulatory proteins
• Homeostasis and bulk flow of extracellular fluid in the CNS
• Impact of CSF dynamics on brain metabolism
• Disrupted transport at the blood-CSF interface in hyperthermia, ischemia and Alzheimer's disease
• Reduced CSF reabsorption in aging, hydrocephalus and dementia

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on December 10, 2018

Financial Disclosures

• Prof. Conrad Johanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.