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- Structure of the blood-brain barrier
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36 min
1. The blood-brain barrier in Alzheimer’s disease- Dr. Anika Hartz
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35 min
2. Tanycytes allow a tight BBB in the median eminence- Prof. Esteban Rodriguez
- Dr. Juan Luis Blazquez
- Dr. Montserrat Guerra
- Nutrient transport
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35 min
3. Blood-brain barrier ion transport- Prof. Martha O'Donnell
- Peptides and proteins
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37 min
4. Ingestive peptides- Prof. William Banks
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62 min
5. Blood-brain barrier in health and disease- Prof. Thomas Davis
- Overcoming the blood-brain barrier obstacle
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42 min
6. Expression vs. function of ABC transporters at the blood-brain barrier- Prof. Jean-Michel Scherrmann
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44 min
7. The blood-brain barrier and CNS drug development- Dr. Danica Stanimirovic
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34 min
- Diseases involving the blood-brain barrier
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71 min
9. Inflammation and immune cell entry to the central nervous system- Prof. Serge Rivest
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42 min
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24 min
11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development- Prof. Ryszard Pluta
- Latest Developments in the Field
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31 min
12. MRI approaches for neurovascular imaging- Dr. Rick Dijkhuizen
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33 min
13. Brain-gut interactions in obesity 1- Prof. Weihong Pan
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19 min
14. Brain-gut interactions in obesity 2- Prof. Weihong Pan
- Archived Lectures *These may not cover the latest advances in the field
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36 min
15. Neurotrophins and the BBB- Prof. Weihong Pan
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52 min
16. Vasoactive peptides and the blood-brain barrier- Prof. Maria Deli
- Prof. Bela Kis
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42 min
17. In vivo systems- Prof. Quentin Smith
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46 min
18. CNS-drug design- Prof. Quentin Smith
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43 min
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23 min
20. Stroke and the BBB- Prof. Marilyn Cipolla
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54 min
21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings- Prof. Norman Saunders
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57 min
22. Barrier mechanisms in the developing brain: protection or vulnerability?- Prof. Norman Saunders
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43 min
23. In vitro models of the blood-brain barrier- Prof. Pierre-Olivier Couraud
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41 min
24. Glucose transport across the blood-brain barrier- Prof. Luc Leybaert
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53 min
25. The blood-brain barrier and brain tumors- Dr. Olaf van Tellingen
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37 min
26. Cellular composition of the blood-brain barrier- Prof. N. Joan Abbott
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48 min
27. Features of mammalian CNS barrier systems- Prof. Conrad Johanson
Printable Handouts
Navigable Slide Index
- Introduction
- Major transport interfaces in CNS
- Features of mammalian CNS barrier systems
- Topical presentation overview (1)
- The choroid plexus system
- Choroid plexus spurs brain development
- Ramifying choroidal fronds and villi
- Ultrastructure of choroidal epithelium
- Schematic reconstruction of villus from EMs
- Topical presentation overview (2)
- Choroid plexus hemodynamics/hydrodynamics
- CSF formation by choroid plexus
- Transport mechanisms in choroidal epithelium
- Pharmacologic modulation of CSF formation
- Neuroendocrine regulation of CSF formation
- Topical presentation overview (3)
- Distribution of choroidal secretions to brain
- Distribution of solutes from blood to brain
- CSF-borne growth factors
- A unique CSF transport pathway
- Disruptions in CSF homeostasis
- Topical presentation overview (4)
- Why study BCSFB permeability and its breakdown
- Quantifying the permeability of the BCSF barrier
- Hypertension disruption of BCSF barrier
- Hyperthermia damage to BCSF barrier
- Ischemia disruption of the BCSF barrier
- Topical presentation overview (5)
- Kidney-like functions of choroid plexus
- CSF turnover rate changes with aging
- Choroid plexus dwindling in late stages of life
- Loss of CSF sink action
- Translational research opportunities
- Conclusions
Topics Covered
- Choroid plexus
- Formation of CSF
- Permeability of blood
- CSF barrier vs. blood-brain barrier
- Choroidal secretion of peptides, growth factors and regulatory proteins
- Homeostasis and bulk flow of extracellular fluid in the CNS
- Impact of CSF dynamics on brain metabolism
- Disrupted transport at the blood-CSF interface in hyperthermia, ischemia and Alzheimer's disease
- Reduced CSF reabsorption in aging, hydrocephalus and dementia
Talk Citation
Johanson, C. (2008, March 1). Features of mammalian CNS barrier systems [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/FOKY4477.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Conrad Johanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
