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- Structure of the blood-brain barrier
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1. The blood-brain barrier in Alzheimer’s disease
- Dr. Anika Hartz
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2. Tanycytes allow a tight BBB in the median eminence
- Prof. Esteban Rodriguez
- Dr. Juan Luis Blazquez
- Dr. Montserrat Guerra
- Nutrient transport
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3. Blood-brain barrier ion transport
- Prof. Martha O'Donnell
- Peptides and proteins
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4. Ingestive peptides
- Prof. William Banks
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5. Blood-brain barrier in health and disease
- Prof. Thomas Davis
- Overcoming the blood-brain barrier obstacle
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6. Expression vs. function of ABC transporters at the blood-brain barrier
- Prof. Jean-Michel Scherrmann
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7. The blood-brain barrier and CNS drug development
- Dr. Danica Stanimirovic
- Diseases involving the blood-brain barrier
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9. Inflammation and immune cell entry to the central nervous system
- Prof. Serge Rivest
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11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development
- Prof. Ryszard Pluta
- Latest Developments in the Field
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12. MRI approaches for neurovascular imaging
- Dr. Rick Dijkhuizen
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13. Brain-gut interactions in obesity 1
- Prof. Weihong Pan
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14. Brain-gut interactions in obesity 2
- Prof. Weihong Pan
- Archived Lectures *These may not cover the latest advances in the field
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15. Neurotrophins and the BBB
- Prof. Weihong Pan
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16. Vasoactive peptides and the blood-brain barrier
- Prof. Maria Deli
- Prof. Bela Kis
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17. In vivo systems
- Prof. Quentin Smith
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18. CNS-drug design
- Prof. Quentin Smith
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20. Stroke and the BBB
- Prof. Marilyn Cipolla
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21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings
- Prof. Norman Saunders
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22. Barrier mechanisms in the developing brain: protection or vulnerability?
- Prof. Norman Saunders
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23. In vitro models of the blood-brain barrier
- Prof. Pierre-Olivier Couraud
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24. Glucose transport across the blood-brain barrier
- Prof. Luc Leybaert
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25. The blood-brain barrier and brain tumors
- Dr. Olaf van Tellingen
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26. Cellular composition of the blood-brain barrier
- Prof. N. Joan Abbott
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27. Features of mammalian CNS barrier systems
- Prof. Conrad Johanson
Printable Handouts
Navigable Slide Index
- Introduction
- Major transport interfaces in CNS
- Features of mammalian CNS barrier systems
- Topical presentation overview (1)
- The choroid plexus system
- Choroid plexus spurs brain development
- Ramifying choroidal fronds and villi
- Ultrastructure of choroidal epithelium
- Schematic reconstruction of villus from EMs
- Topical presentation overview (2)
- Choroid plexus hemodynamics/hydrodynamics
- CSF formation by choroid plexus
- Transport mechanisms in choroidal epithelium
- Pharmacologic modulation of CSF formation
- Neuroendocrine regulation of CSF formation
- Topical presentation overview (3)
- Distribution of choroidal secretions to brain
- Distribution of solutes from blood to brain
- CSF-borne growth factors
- A unique CSF transport pathway
- Disruptions in CSF homeostasis
- Topical presentation overview (4)
- Why study BCSFB permeability and its breakdown
- Quantifying the permeability of the BCSF barrier
- Hypertension disruption of BCSF barrier
- Hyperthermia damage to BCSF barrier
- Ischemia disruption of the BCSF barrier
- Topical presentation overview (5)
- Kidney-like functions of choroid plexus
- CSF turnover rate changes with aging
- Choroid plexus dwindling in late stages of life
- Loss of CSF sink action
- Translational research opportunities
- Conclusions
Topics Covered
- Choroid plexus
- Formation of CSF
- Permeability of blood
- CSF barrier vs. blood-brain barrier
- Choroidal secretion of peptides, growth factors and regulatory proteins
- Homeostasis and bulk flow of extracellular fluid in the CNS
- Impact of CSF dynamics on brain metabolism
- Disrupted transport at the blood-CSF interface in hyperthermia, ischemia and Alzheimer's disease
- Reduced CSF reabsorption in aging, hydrocephalus and dementia
Talk Citation
Johanson, C. (2008, March 1). Features of mammalian CNS barrier systems [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/FOKY4477.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Conrad Johanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.