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1. Introduction
2. Sites of CNS barriers
3. Topics
4. The neurovascular unit
5. What is the neurovascular unit?
6. Gliovascular unit at microvessel level (1)
7. Neurovascular unit modulation
8. Brain capillaries
9. The BBB and associated cells
10. Blood-brain barrier structure: capillary
11. Functions of the BBB
12. Molecular structure of BBB junctions
13. Pathways across the blood-brain barrier
14. Biomarkers for a differentiated BBB (1)
15. Biomarkers for a differentiated BBB (2)
16. Differential gene expression at the BBB
17. Supporting cell types at the BBB
18. Cell types at the BBB
19. Induction of BBB in brain endothelium
20. BBB induction in ingrowing vessels by brain tissue
21. Perivascular astrocyte morphologies
22. Astrocytes
23. Gliovascular unit at microvessel level (2)
24. Astrocytic influence on endothelial tight junctions
25. Co-culture upregulates antioxidant enzymes
26. Endothelium and astrocytes mutual induction
27. Regulation of gamma-GTP activity by astrocytes
28. Regulation of brain endothelial AQP1
29. Proposed model for ISF production and circulation
30. Glial induction of brain endothelium
31. Endothelial induction of glial cells
32. Important features of pericytes
33. Pericytes stabilize capillary-like structures
34. Migrating pericytes produce angiogenic factors
35. Pericytes role in control of capillary diameter
36. Pericytes can control capillary blood flow
37. Induction of the BBB
38. Summary of BBB induction
39. Microglia
40. Mast cells
41. Mast cell morphology and interaction with neurons
42. Smooth muscle cells
43. Regulation of cerebral blood flow
44. Regulation of BBB permeability
45. Brain endothelial junctional zone components
46. Molecular interactions at the tight junction
47. Agents that alter BBB permeability
48. BBB heterogeneity
49. Tight junctional strands in brain vasculature
50. Perivascular niche in post-capillary venules
51. Summary of perivascular niche events
52. BBB and perivascular niche
53. BBB changes in pathology
54. The BBB is involved in many CNS pathologies
55. BBB modulation in pathology
56. Conclusions
57. Acknowledgements

Topics Covered

• Sites of CNS barriers
• Neurovascular unit
• Blood-brain barrier (BBB) at brain capillary endothelium
• Functions of BBB
• Tight junctions
• Pathways across the BBB
• BBB biomarkers
• Supporting cell types
• Astrocytes and BBB induction
• Pericytes
• Microglia
• Mast cells
• Smooth muscle
• BBB modulation
• Heterogeneity
• Changes in pathology

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on December 10, 2018

Financial Disclosures

• Prof. N. Joan Abbott has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.