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Printable Handouts
Navigable Slide Index
- Introduction
- Lateral gene transfer
- The integron/gene cassette system
- Arrangement of integron/gene cassette system
- The recombination system
- Three components of an integron
- Gene cassettes
- Circular form of genes cassettes
- Linear form of a gene cassette
- Gene cassette capture
- Recombination occures in two directions
- What integrons can do
- Cassette associated genes
- Integrons and multi drug resistance
- Example: resistance genes in class 1 integrons
- Examples of class 1 integron arrays
- Cassettes can appear in different contexts
- The cassette recombination site
- Cassette recombination site structure
- 59-be sites are imperfect inverted repeats
- Examples of 59-be sites
- A typical cassette
- Elements in linear cassettes are hybrids
- Integron/gene cassette biology
- Integrons in pathogens
- Integron classes (1)
- Integron classes (2)
- Distribution of chromosomal integrons
- Chromosomal integrons have large arrays
- Cassette genes are novel (1)
- Cassette genes are novel (2)
- Reminder: integron/gene cassette biology
- How have class 1 integrons been spread?
- Functional features of class 1 integrons
- Class 1 integrons have additional features
- Two definitions of class 1 integrons
- Physical structure of class 1 integrons
- Evolution of class 1 structure
- Ancestral structure: Tn402
- Tn402 - a transposon and a functional integron
- Inverted repeats allow transposition of integrons
- Spread of class 1 integrons
- A transposon in transposons
- Class 1 integrons in the Tn3 family
- Mobile elements interact
- Consquence of spreading resistance genes
- Other mobilized integron classes exist
- References
Topics Covered
- A description of the integron/gene cassette system
- Integrons in the general environment
- Class 1 integron mediated spread of antibiotic resistance genes in pathogens
- How class 1 integrons work with plasmids and transposons to spread between cells
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Talk Citation
Stokes, H. (2008, January 28). Plasmids, integrons and the spread of antibiotic resistance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/FFUW6017.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Hatch Stokes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.