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Navigable Slide Index

1. Introduction
2. Preface
3. Terminology
4. Mechanism of action of PSK systems
5. Types of PSK
6. Typical proteic PSK
7. The Ccd system of plasmid F
8. The CcdA protein
9. CcdA-CcdB binding to DNA
10. Toxin-antitoxin structure
11. CcdB target: gyrase
12. GyrA binding of CcdB
13. Toxin-antitoxin families
14. Alternative arrangements of PSK systems
15. Modular organization of antitoxins
16. Chromosomally encoded proteic TA systems
17. Antisense-RNA regulated PSK loci
18. The problem with antisense RNA systems
19. The R1-encoded hok/sok locus
20. hok/sok solution to toxin mRNA persistence
21. Target of the Hok toxin: ghost cell formation
22. The pAD1 par locus
23. RNA I and RNA II secondary structures
24. Mechanism of RNA I-RNA II interaction
25. The RNA I-RNA II complex is unusually stable
26. Fst effects on chromosome segregation
27. Fst effects on cell division
28. Final note of caution
29. Review (general)
30. Review (proteic systems)
31. Review (antisense RNA regulated systems)

Topics Covered

• Introduction to post-segregational killing systems
• Proteic post-segregational killing systems
• The Ccd system
• Other proteic systems
• Antisense RNA-regulated post-segregational killing systems
• The plasmid R1 hok/sok system
• The plasmid pAD1 par system

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Genetics & Epigenetics
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 28, 2008

Financial Disclosures

• Prof. Keith Weaver has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.