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1. Introduction
2. Outline
3. The plasmid lifestyle
4. Plasmids don't want to get lost
5. Plasmids run a high risk of getting lost
6. Negative feedback control of plasmid replication
7. Plasmid R1
8. General properties
9. Copy number control of plasmid R1
10. Indirect inhibition and translational coupling
11. Interaction between folded RNAs
12. Copy number control of ColE1-type plasmids
13. Regulation by induced RNA folding change
14. Copy number control of plasmid pIP501
15. RNAIII induces transcription termination
16. Copy number control of IncI-alpha/IncB plasmids
17. Inhibition of activator pseudoknot
18. Different mechanisms - same principle
19. Kinetic control of copy number
20. Binding pathways - a hierarchy of steps
21. The CopA/CopT four helix junction structure
22. Special tricks for fast RNA-RNA recognition
23. Helper proteins
24. Acknowledgements

Topics Covered

• Negative feedback control of plasmid replication
• General properties of plasmids
• Plasmid R1
• Copy number control of plasmid R1
• Inhibition and translational coupling
• Interaction between folded RNAs
• Copy number control of ColE1-type plasmids
• Regulation by induced RNA folding change
• Copy number control of plasmid pIP501
• RNAIII induces transcription termination
• Copy number control of IncIa/IncB plasmids
• Inhibition of activator pseudoknot
• Kinetic control of copy number
• Binding pathways: a hierarchy of steps
• The CopA/CopT four helix junction structure
• Fast RNA-RNA recognition
• Helper proteins

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Genetics & Epigenetics
• Methods
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 28, 2008
• Reviewed on April 30, 2023

Financial Disclosures

• Prof. Gerhart Wagner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.