• Introduction and General Properties of Plasmids
• 31 min
  1. Introduction to plasmid biology

  • Prof. Emeritus Don Clewell
• 39 min
  2. General properties and applications of plasmids

  • Prof. Emeritus Don Clewell
• Replication
• 47 min
  3. Plasmids: copy number control by antisense RNAs

  • Prof. Gerhart Wagner
• 30 min
  4. Plasmid rolling-circle (RC) replication

  • Prof. Saleem Khan
• 45 min
  5. Replication of linear plasmids in bacteria

  • Prof. George Chaconas
• Maintenance and Partitioning
• 32 min
  6. Plasmid segregation and stability in bacteria

  • Prof. Barbara Funnell
• 33 min
  7. Plasmid stabilization by cell killing

  • Prof. Keith Weaver
• 30 min
  8. Dimer catastrophes and plasmid resolution

  • Dr. David Summers
• Conjugation and Mobilization
• 41 min
  9. The diversity of bacterial conjugation and mobilization systems

  • Prof. Fernando de la Cruz
• 36 min
  10. The pCF10-encoded pheromone response: cell-cell signaling, complexity and evolution

  • Prof. Gary Dunny
• 27 min
  11. DNA processing in conjugative transfer

  • Dr. Joel Schildbach
• 43 min
  12. Agrobacterium tumefaciens

  • Dr. Stephen Winans
• Genetic Traits Frequently Associated with Plasmids
• 37 min
  13. Insertion sequences and DNA transposition

  • Prof. William Reznikoff
• 48 min
  14. Plasmids, integrons and the spread of antibiotic resistance

  • Prof. Hatch Stokes
• 30 min
  15. Virulence plasmids

  • Prof. Julian Rood
• Eukaryotic Plasmids
• 30 min
  16. The yeast plasmid: a highly persistent selfish DNA element

  • Prof. Makkuni Jayaram
• Population Biology and Evolution
• 35 min
  17. Evolution of plasmids and their role in bacterial diversity and adaptability

  • Prof. Christopher Thomas
• Archived Lectures *These may not cover the latest advances in the field
• 85 min
  18. Bacterial extrachromosomal elements: role in chemical detoxification and potential cancer therapy

  • Prof. Ananda Chakrabarty
• 34 min
  19. Plasmid segregation and stability in bacteria

  • Prof. Barbara Funnell
• 39 min
  20. Replication of linear plasmids in bacteria

  • Prof. George Chaconas

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Bacterial cell with plasmid DNA
3. Ubiquity of plasmids
4. The prokaryotic world
5. Horizontal gene transfer
6. Conjugation
7. Bacterial pilus
8. Sex pheromone response
9. Single strand transfer
10. Plasmid integration into the chromosome
11. Mobilization of the chromosome
12. Homologous recombination
13. Joshua Lederberg
14. William Hayes
15. Resistance factors identified in Japan
16. Multiple resistance transfer
17. Bacteriocins
18. Zones of inhibition
19. Episome vs. plasmid
20. Plasmid nomenclature
21. Mating experiment
22. Conformation of plasmids
23. Nicking of supercoiled plasmids
24. Electron microscopy of ColE1 (1)
25. Electron microscopy of ColE1 (2)
26. Size of plasmids
27. Megaplasmids
28. Vibrio cholera genome
29. Replicon
30. Initiation of replication
31. Partitioning
32. Curing
33. Multiple plasmids and copy number
34. Mixtures of circular and linear plasmids
35. Plasmids as viral genomes
36. Genes frequently found on plasmids
37. Transposons
38. Classification of plasmids
39. Cytoplasmic elements in higher systems
40. Summary

Topics Covered

• Ubiquity of plasmids
• The prokaryotic world
• Conjugation
• Common traits encoded by plasmids
• Conformation
• Maintenance
• Classification
• Higher systems

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Genetics & Epigenetics
• Methods
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 28, 2008
• Reviewed on April 16, 2023

Financial Disclosures

• Prof. Emeritus Don Clewell has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.