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See webinar details- Introduction
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3 min
1. Editor's foreword- Prof. Ann Daly
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47 min
2. Introduction to drug metabolism enzymes- Dr. Dennis Smith
- General factors affecting drug metabolism
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30 min
3. General factors affecting drug metabolism: effect of physiological factors and disease 1- Prof. Edward T. Morgan
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24 min
4. General factors affecting drug metabolism: effect of physiological factors and disease 2- Prof. Edward T. Morgan
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39 min
5. Drug metabolism in liver disease- Dr. Nathalie Zgheib
- Prof. Robert Branch
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37 min
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50 min
7. Prediction of pathways of drug metabolism- Dr. Maurice Dickins
- Phase I metabolizing enzymes: cytochrome P450s
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45 min
8. Cytochrome P450 1 family: the roles of 1A1, 1A2 and 1B1 in drug metabolism- Prof. F. Peter Guengerich
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42 min
9. CYP2 family- Prof. Ann Daly
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52 min
10. Why study the cytochrome P4503A (CYP3A) family?- Dr. Erin Schuetz
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54 min
11. Pharmacogenomics: an update- Prof. Magnus Ingelman-Sundberg
- Phase I metabolizing enzymes: non-cytochrome P450s
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45 min
12. Non-P450 oxidative metabolism: characteristics and drug substrates- Dr. Christine Beedham
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53 min
13. UDP-glucuronosyltransferases- Prof. Abby Collier
- Phase II metabolizing enzymes: conjugating enzymes
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31 min
14. Glutathione transferases- Prof. Ralf Morgenstern
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31 min
15. Arylamine N-acetyltransferases 1- Prof. Edith Sim
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23 min
16. Arylamine N-acetyltransferases 2- Prof. Edith Sim
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19 min
17. Arylamine N-acetyltransferases 3- Prof. Edith Sim
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56 min
18. Methyltransferases- Prof. Richard Weinshilboum
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22 min
19. Amino acid conjugation: mechanism and enzymology- Dr. Kathleen Knights
- Clinical aspects
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33 min
20. Clinical significance of enzyme induction and inhibition- Prof. Kim Brøsen
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39 min
21. Clinical importance of pharmacogenetic polymorphisms affecting drug metabolism- Prof. Julia Stingl (formerly Kirchheiner)
- Latest Updates in the Field
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34 min
22. Mammalian flavin-containing monooxygenases- Prof. Allan Rettie
- Archived Lectures *These may not cover the latest advances in the field
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54 min
23. Glucuronidation and the UDP - glucuronosyltransferases- Prof. Peter Mackenzie
- Prof. John Miners
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38 min
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28 min
25. Catalytic cycle of cytochrome P450s- Prof. Gordon Roberts
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40 min
26. Drug metabolism and liver disease- Prof. Robert Branch
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46 min
27. Crystal structures of drug-metabolizing P450 monooxygenases- Prof. Eric Johnson
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49 min
28. Sulfation and human cytosolic sulfotransferases- Prof. Charles Falany
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50 min
29. Laboratory methods for the in vitro study of drug metabolism- Dr. Charles Crespi
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45 min
30. Clinical importance of pharmacogenetic polymorphisms affecting drug metabolism: psychopharmacology and pain- Prof. Julia Stingl (formerly Kirchheiner)
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51 min
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53 min
32. Pharmacogenomics- Prof. Magnus Ingelman-Sundberg
Printable Handouts
Navigable Slide Index
- Glucuronidation and UGT
- Content of presentation
- The glucuronidation reaction
- UDP-glucuronic acid
- Glucuronidation reaction scheme
- Glucuronidation - detox. mechanism
- UGT substrates - aliphatic alcohols
- UGT substrates - phenols
- UGT substrates - carboxylic acids
- UGT substrates - amines
- UGT substrates - thiols and AC
- Sites for glucuronidation
- Compounds eliminated by glucur.
- Human UGTs
- Substrate selectivity of human UGTs
- UGT1A pharmacophores
- UGT isoform expression
- UGT isoform selectivity of bilirubin
- UGT isoform selectivity of testos.
- UGT isoform selectivity of trifluop.
- UGT isoform selectivity of AZT
- UGT substrate selectivity
- UGT gene family
- UGT1 family
- UGT2 family
- Topology model and dimerization
- UGT domains
- Topology model
- Dimerization of UGT
- Dimerization of UGT - implications
- UGT gene expression
- Tissue-specific expression of UGTs
- UGT gene expression
- Hepatic UGT2B gene transcription
- UGT2B proximal promoters
- UGT1A7-10 gene transcription
- UGT structure-function relationship
- The human UGT1A gene locus
- UGT2B2/UGT2B3 hybrid proteins
- Binding domain of UGT2B15
- Structural domains of UGT
- UGT genetic polymorphism
- Disorders of bilirubin glucuronidation
- UGT1A1 polymorphism
- UGT1A1 - TA repeat number
- Effect of UGT1A1*6 (G71R)
- UGT1A1 allele frequencies
- Influence of UGT2B15 genotype
- UGTs and adverse events
- Kinetics of xenobiotic glucur. in vitro
- Bisubstrate kinetics
- UGT kinetics - empirical models
- Zidovudine glucuronidation
- 4-methylumbelliferone glucur.
- "Two site" kinetic model
- 4-methylumbelliferone glucur.
- UGT inhibition and drug interactions
- Effect of fluconazole on UGT
- Hecogenin - inhibitor of UGT1A4
- Human hepatic UGT isoforms
- Inhibition of human UGTs
- Drug interactions
- UGT reviews
- Contact
Topics Covered
- The glucuronidation reaction
- UGT enzyme superfamily
- Importance for xenobiotic and drug metabolism
- Substrate and inhibitor specificities
- Gene regulation
- Tissue specific expression
- Genetic polymorphism
- Structure/function relationships
- Kinetic considerations
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Mackenzie, P. and Miners, J. (2007, October 1). Glucuronidation and the UDP - glucuronosyltransferases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 13, 2025, from https://doi.org/10.69645/MFGX4670.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Mackenzie has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. John Miners has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
