CYP2 family

Published on October 1, 2007 Updated on July 27, 2016   42 min

Other Talks in the Series: Drug Metabolizing Enzymes

Hello. I'm Ann Daly. And in the next 50 minutes or so I'm going to introduce you to the CYP2 cytochrome P450 family and its role in drug metabolism.
In terms of number of members, CYP2 is the largest human cytochrome P450 family, with about 30% of all human isoforms found here. There are over 20 different subfamilies in CYP2. But I'm going to concentrate on the main subfamilies that contribute to drug metabolism here. As shown, there are five of these subfamilies, CYP2A, CYP2B, CYP2C, CYP2D, and CYP2E. Each of these contain between one and three drug metabolizing isoforms. Other important CYP2 subfamilies include CYP2S and CYP2J. But I'm not going to consider these further as they mainly metabolize endogenous compounds rather than drugs and other xenobiologics.