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1. Introduction
2. Unique features of alloreactivity
3. Estimating frequency of alloreactive T cells in vivo
4. Alloreactive precursor frequency
5. Tolerance approaches
6. T cells costimulatory pathways
7. Blockade induces transplant tolerance
8. Distinct effects of CD28 costimulation
9. Apoptotic T cells induce transplantation tolerance
10. Calcineurin inhibition antagonizes blockade
11. Antagonism of blockade and calcineurin inhibitors
12. Reduction in T cells number facilitates tolerance
13. How to delete alloreactive cells?
14. Homeostatic proliferation
15. Homeostatic proliferation: a barrier to tolerance
16. Homeostatic proliferation and memory generation
17. Memory-like functional responses
18. Memory T cells abrogate graft prolongation
19. Cardiac allograft rejection in scid mice
20. Scid mice resist tolerance induction
21. Homeostatic proliferation of B6 T cells
22. T cells depletion leads to proliferation (1)
23. T cells depletion leads to proliferation (2)
24. Incomplete T cells depletion affects tolerance
25. Do memory cells develop due to failure to tolerize?
26. BrdU incorporation in transferred B6 T cells
27. Cardiac allograft rejection
28. Failure to maintain suppressor cells
29. % of CD4+CD25+ after homeostatic proliferation
30. T cells from reconstituted scid mice
31. Reconstituting normal mice made T-cell deficient
32. Failure to tolerize after homeostatic proliferation
33. Reduction in clonal mass facilitates tolerance
34. Heterologous immunity: a barrier to tolerance (1)
35. Heterologous immunity: a barrier to tolerance (2)
36. Memory cells in partial depletion, lymphopenia
37. Various types of cells in the aftermath of depletion
38. Differential depletion
39. Sparing of memory T cells after depletion
40. Differential proliferation
41. Testing differential proliferation
42. Proliferation of memory T cells after depletion (1)
43. Proliferation of memory T cells after depletion (2)
44. Depletion doesn't alter the proportion of CD4 cells
45. CD4+CD25+ Tregs versus non-regulatory T cells
46. Prevention of rejection of homeostatic proliferation
47. Restoring tolerance induction by Tregs
48. Restoring tolerance induction by anti-CD4/CD8
49. Anti-CD4/CD8 block homeostatic proliferation
50. Why is transplant tolerance hard to achieve?
51. Acknowledgements

Topics Covered

• Overview of alloreactivity
• Tolerance approaches
• Co-stimulatory blockade
• Requirement for cell depletion
• Homeostatic proliferation overview
• Homeostatic proliferation generates memory cells and blocks tolerance induction
• Depletion spares memory cells

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Immunology
• Methods

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Turka, L. (2007, October 1). Antibody depletion therapy in transplantation: implications for tolerance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/NEPF3205.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Laurence Turka has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.