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Navigable Slide Index

1. Introduction
2. New lymphocyte membrane proteins
3. Purification of lymphocyte surface proteins
4. Leukocyte membrane proteins domains (1)
5. Leukocyte membrane proteins domains (2)
6. Variable abundance of membrane glycoproteins
7. Glycosylation of lymphocyte surface proteins
8. Glycosylation of membrane proteins
9. Variable size of membrane glycoproteins
10. Size of membrane proteins
11. mAb binds cell surface proteins very effectively
12. Roles of leukocyte membrane proteins
13. Identification of leukocyte surface receptors
14. CD200 binds macrophages and blocked by mAb
15. CD200-CD200 receptor: macrophage regulation
16. Membrane protein interactions are low affinity
17. Membrane protein interactions
18. How do mAb work as drugs?
19. Properties of mAb important
20. Affinity of mAb
21. Affinity of mAb: the OX7 mAb
22. Affinity of mAb: the CD147 mAb
23. Affinity of mAb: kinetics
24. Where does the mAb bind?
25. Some targets are small surface proteins
26. Summary

Topics Covered

• Lymphocyte cell surface
• Membrane proteins
• Identification of interactions
• Protein microarrays
• Monoclonal antibodies
• Recombinant proteins
• Characterization of interactions at a molecular level
• Reaction kinetics
• Protein structure
• Role of engagement
• Role in disease and potential therapies

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Barclay, N. (2022, April 12). Cell surface glycoproteins on cells of the immune system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/JTGT2374.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Reviewed on April 12, 2022

Financial Disclosures

• Prof. Neil Barclay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.