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Hello. My name is
Malú Gámez Tansey.
I am a professor of
Neuroscience and Neurology at
the University of Florida,
College of Medicine.
Today I'm going to talk
to you about the role of
inflammation in the pathogenesis
of Parkinson's disease.
0:19
Here are my disclosures.
0:22
I'd like to begin by
reminding you that there are
unifying mechanisms
of neurodegeneration
that are shared across
neurodegenerative diseases.
There are five or six main
areas of mechanistic overlap.
These include aging,
environmental factors
such as age, diet,
exercise and lifestyle,
head injuries, pesticide,
solvent exposure.
Metabolic and oxidative stress
is another main category.
Genetic contributors, the
neovascular coupling or
blood brain barrier breakdown.
Finally, neuroinflammation and
the central-peripheral
neuroimmune crosstalk
with organs outside the brain.
We are particularly
interested in this last one,
neuroinflammation and
central peripheral
neuroimmune crosstalk and
its complex interactions
with the other
unifying mechanisms.
1:22
We are particularly interested
in the neuroimmune
crosstalk between
central and peripheral
compartments
which is very critical
for brain health.
The reason for this is because
the brain is not
immune privileged.
If anything, it's
immune specialized.
What this means is that
substances cross from
the periphery across
the blood brain barrier
into the central nervous system,
and substances are able to
cross even when
there's alterations.
But the traffic of
these substances
and the cells becomes
disregulated.
