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1. Introduction
2. Biological activity of Ab is a critical component
3. B cell-directed immunotherapies
4. Antigen expression during B cell development
5. B lymphocyte targets for immunotherapy
6. CD20 immunotherapy for lymphoma
7. CD20-directed immunotherapies (1)
8. CD20-directed immunotherapies (2)
9. CD20 immunotherapy for lymphoma - rituximab
10. Key Ab properties for Ab-mediated immunotherapy
11. Antibody structure and classes
12. Affinity and avidity
13. Immunogenicity (1)
14. Immunogenicity (2)
15. Half-life
16. Ab effects on B cell function
17. CD20: function, structure and expression
18. CD20 hypothetical structure on B lymphocytes
19. CD20 complex-mediated Ca2+ conductance
20. Ab binding to CD20 inhibits decrease in [Ca2+]i
21. CD20-deficient B cell [Ca2+]i responses
22. Membrane spanning-4A gene family
23. MS4a expression by mouse tissues
24. Antibody effects on B cell function
25. Antibody dependant cellular cytotoxicity
26. Mouse anti-mouse CD20 monoclonal antibodies
27. MB20 mAb depletion of B cells in vivo
28. CD20 mAb effects on bone marrow B cells
29. CD20 mAb depletes blood B cells
30. CD20 mAb depletes spleen B cells in vivo
31. CD20 mAb eliminates majority of mature B cells
32. B cell depletion after CD20 mAb treatment
33. The peritoneal cavity provides a protective niche
34. Inflammation abrogates the protective niche
35. FcR expression is required for B cell depletion
36. B cell depletion by CD20 requires monocytes
37. CD20 antibodies induce ADCC
38. Complement dependent cytotoxicity (CDC)
39. B cell depletion does not require C'/ T/ NK cells
40. Mouse survival following A20 lymphoma inoculation
41. CD20 treatment eliminates most of mature B cells
42. Non-responsiveness and resistance to CD20 mAb
43. CD20 immunotherapy for autoimmunity
44. S.c CD20 mAb administration is effective
45. B cell depletion in TSK/+ mice by CD20 mAb
46. B cell depletion reduces skin fibrosis
47. CD20-directed immuotherapies
48. Mechanistic studies of CD20 mAb immunotherapy

Topics Covered

• Antibody targeting of B-cell malignancies and autoimmunity
• CD20 antibody immunotherapy
• CD20 structure and function
• Antibody-dependent cellular cytotoxicity
• Complement-dependent cytotoxicity
• Mouse models of CD20 immunotherapy
• Lymphoma immunotherapy
• Immunotherapy for autoimmunity

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Tedder, T. (2007, October 1). CD20 antibodies in the targeting of B-cell malignancies and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/GIRG6026.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on June 13, 2019

Financial Disclosures

• Prof. Thomas Tedder has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.