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1. Introduction
2. Antibodies
3. Mammalian antibody classes
4. Mammalian antibody classes (schematic)
5. Mammalian antibody subclasses
6. Monoclonal antibodies as therapeutic agents
7. IgG is the preferred class
8. Crystal structure of whole IgG2a
9. Antibody modes of action
10. Fc receptors - introduction
11. Fc receptors
12. Characteristics of human IgG Fc receptors
13. Human IgG Fc receptors
14. Cell distribution and expression of FcR
15. Cell activation by immune complexes
16. Cell inhibition by immune complexes
17. IgG1-FcRIII complex crystal structure
18. The Brambell receptor or FcRn
19. The IgG receptor FcRn
20. Effect of half-life on antibody concentration
21. Pathogen encoded HSV-1 FcR
22. Binding of human IgG to cells infected with HSV-1
23. Binding of human IgG1 allotype variants to cells
24. Human IgG glycosylation effect on binding to cells
25. IgG1 allotypes and HSV-1 FcR binding
26. IgG1 allotypes
27. Effector functions and therapy
28. Rodent monoclonal antibodies for therapy
29. Effector functions of rodent antibodies (ADCC)
30. Effector functions of rat antibodies
31. Campath-1 CD52 antigen
32. Therapeutic use of Campath-1(CD52) antibodies
33. Therapy with rat CD52 antibodies
34. Serotherapy with rat IgG2b Campath-1G
35. Mechanism of action of Campath-1G Ab
36. Problems with use of rodent antibodies for therapy
37. Human antibodies for therapeutic applications
38. Humanizing the rat IgG2b Campath-1G antibody
39. Effector functions of human isotypes
40. Rat IgG2b is effective in therapy
41. Human IgG1 also effective in therapy
42. Effector functions of human IgG
43. Summary
44. Acknowledgements

Topics Covered

• Antibody classes and subclasses
• General Ab structure
• Modes of action
• Fc receptors
• General FcR structures
• Cellular expression
• Triggering by immune complexes
• Neonatal FcR
• Antibody half-life
• Viral FcR
• Antibody allotypes
• Therapeutic use of monoclonal antibodies
• Mechanisms of action
• Antiglobulin responses
• Antibody humanization

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Requested.