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0:00
Thank you for inviting
me to give a talk
on the immune system
across childhood.
My name is Jayshree R. S. and
I was formerly associated with
the Department of
Microbiology at
Kidwai Memorial Institute of
Oncology Bangalore, India.
0:20
Well, what I want to
do in this lecture
is to provide a
detailed description of
the immune system across
various stages of
childhood from life in
utero to adolescence.
This aspect has been
very well researched
in recent years and
so I will not be
going into the intricacies
of molecular signaling
of each step but will
broadly cover the subject.
I hope this would be a
good starting point for
people to get an overall
view of the immune system at
various time points during
childhood and would
preferably serve as a primer
for their specific
areas of research.
A broad outline of the
lecture will be as follows.
Under the subheading of
in utero immune system,
I will cover the development
of the immune system,
the part played by
the placenta in the
fetal immune system,
innate cellular and
humoral immune systems
and adaptive cellular and
humoral immune systems.
Under the section of immune
system in early childhood,
I will describe the
significance of
the first hundred
days of life for
establishment of
eubiotic microflora
in the neonates'
gastrointestinal tract.
The development of immune
tolerance to the gut flora and
self antigens and the role
played by breast milk
in this process.
I will also detail
the development of
the innate cellular and
humoral immune systems and
adaptive cellular and
humoral immune systems in
early childhood and speak in
depth about various
components of these.
Under the subdivision immune
system in late childhood,
I will explain
puberty-induced changes
in the immune system
specifically synthesis
of hormones and
expression of hormone
receptors in immune cells,
T cell development, function,
thymic involution and
B cell development.
