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Navigable Slide Index

1. Introduction
2. Derivation of transgenic lines
3. Introduced human Ig loci expressed in mice
4. Ig heavy and light chain knock-out mice
5. Human translocus integration in Ig KO mice
6. Expression of human IgM in mice
7. Analysis of Ab producing B-cells by flow cytometry
8. Analysis of B-cell development
9. The human antibody response
10. Human anti-human Abs from immunized mice
11. Pentameric IgM
12. V-D-J junction and hypermutation in mice
13. Fully human antibodies in pre-clinical trials

Topics Covered

• Immune development
• Human Ig loci
• Transgenesis
• Human antibody repertoires
• Monoclonal human antibodies
• Silencing mouse antibody production
• B-cell receptor structure
• Flow cytometry
• Therapeutic Ig

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Immunology
• Methods

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Dr. Marianne Bruggemann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.