Tissue factor and factor VII: initiation of blood coagulation

Published on October 1, 2007 Reviewed on December 15, 2015   26 min

Other Talks in the Series: Protein Epidemiology

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The title of this module is Tissue Factor and Factor VII -.Initiation of Blood Coagulation. My name is John McVey. The learning objectives are to introduce the coagulation network,
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to give you an understanding of how this complex process is regulated, and how it functions at the molecular level. In particular, focusing on the role of Tissue Factor and Factor VII complex in initiating coagulation, looking at their structure and function but also the role of tissue factor pathway inhibitor and regulating the activity of this initiation complex. Finally, I will discuss the pathophysiological consequences of inappropriate expression or deficiency.
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The ability to stem the flow of body fluids at the sight of vascular injury is a very primitive defense mechanism. This is critical for the survival of any multicellular organism, both in preventing loss but also preventing entry of organisms and pathogens. Organisms have adopted a variety of different methods to achieve this, tissue contraction, cellular aggregation, and the formation and deposition of molecular glues.
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Tissue factor and factor VII: initiation of blood coagulation

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