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- Fundamentals of Evolution and Medicine
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1. Evolutionary medicine
- Prof. Randolph Nesse
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2. Evolution and medicine: from the perspective of an evolutionary biologist
- Prof. Stephen C. Stearns
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3. Developmental plasticity, evolution and the origins of disease
- Dr. Mary Jane West-Eberhard
- Evolutionary Genetics
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4. Genetic variation and human disease
- Dr. David Houle
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6. Ecogenetics, evolutionary biology and human disease
- Prof. Gilbert Omenn
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7. Race in genetics and medicine
- Prof. Jeffrey Long
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8. Health disparities in common complex diseases: a role for genetics?
- Dr. Kathleen Barnes
- Infectious Disease
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10. Evolutionary arms races
- Prof. Mark Pagel
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11. Antibiotic resistance and hospital-acquired infection
- Dr. Carl Bergstrom
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12. Evolution of drug resistance
- Dr. Pleuni Pennings
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13. Evolution of virulence: malaria, a case study
- Prof. Andrew Read
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14. Infection and chronic disease
- Prof. Paul Ewald
- Defenses
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15. Fever and related defenses
- Prof. Matthew Kluger
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16. The evolutionary ecology of immunity
- Prof. Paul Schmid-Hempel
- Novel Environmental Factors
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17. What did humans evolve to eat? evolutionary perspectives on human nutritional health
- Prof. William R. Leonard
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19. The paleolithic lifestyle and prevention of chronic disease
- Prof. S. Boyd Eaton
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22. Diseases of civilization: an evolutionary legacy
- Prof. Alan Weder
- Problems Arising From Constraints and Trade-Offs
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23. Aging and evolutionary medicine
- Prof. Linda Partridge
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24. Human aging and menopause
- Prof. Kristen Hawkes
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25. Why we cook with spices: preventative darwinian medicine
- Prof. Paul Sherman
- Sex and Reproduction
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26. Setting the second stage: the evolution of menopause & post-reproductive life
- Prof. Lynnette Sievert
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27. Evolutionary obstetrics
- Prof. Wenda Trevathan
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28. Sex differences in mortality
- Dr. Daniel Kruger
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29. The endocrinology of human life history transitions
- Prof. Peter Ellison
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30. Genetic conflicts in human pregnancy
- Prof. David Haig
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31. Environmental effects on human reproduction
- Prof. Gillian Bentley
- Cancer
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32. A darwinian eye view of cancer
- Prof. Mel Greaves
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33. Viruses and cancer
- Prof. Robin Weiss
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34. Connecting aging and cancer through the lens of evolution
- Prof. James DeGregori
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35. Evolutionary dynamics in cancer control and cure
- Dr. Bob Gatenby
- Specific Body Systems
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36. Hard tissue biology in human health and evolution: enamel biology
- Prof. Timothy Bromage
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37. Hard tissue biology in human health and evolution: bone biology
- Prof. Timothy Bromage
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38. Hard tissue biology in human health and evolution: craniofacial biology
- Prof. Timothy Bromage
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39. Hard tissue biology in human health and evolution: life history and chronobiology
- Prof. Timothy Bromage
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40. Lung biology and lung disease
- Prof. John S. Torday
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41. The evolutionary web of life
- Prof. John S. Torday
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42. Evolutionary considerations and the endothelium
- Dr. William Aird
- Mental Disorders
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43. Evolutionary psychiatry
- Prof. Randolph Nesse
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44. Evolutionary behavioural genetics and mental disorders
- Dr. Matthew Keller
- Questions and Answers
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45. Audience questions about evolution and medicine
- Prof. Randolph Nesse
- Paediatrics
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46. Evolutionary pediatrics
- Dr. Paul Turke
- Microbiome
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47. Evolution, the microbiome, and human health
- Dr. Joe Alcock
- Archived Lectures *These may not cover the latest advances in the field
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48. The hygiene hypothesis
- Prof. Graham Rook
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49. Mapping motivations: evolutionary health promotion
- Dr. Valerie Curtis
- Dr. Robert Aunger
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50. Evolutionary biology of depression
- Prof. Lewis Wolpert
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51. Evolutionary genetic epidemiology
- Prof. Nicholas Schork
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52. Mental disorders in the light of evolutionary biology
- Prof. Randolph Nesse
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53. Evolution: medicine's missing basic science
- Prof. Randolph Nesse
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54. Environmental effects on human reproduction
- Prof. Gillian Bentley
Printable Handouts
Navigable Slide Index
- Introduction
- What is evolutionary medicine?
- Medicine and evolutionary biology
- The growth of evolutionary medicine
- Traits need two kinds of explanation
- Natural selection
- All modern domestic dogs are descendants of the gray wolf
- Selection shapes adaptations
- Apparent maladaptation
- Tinbergen's 4 questions
- Timbergen's 4 questions, organized
- The paradox
- Amazing perfection
- Crude imperfection
- A new question
- The usual question
- The evolutionary question
- Darwin made two discoveries
- Phylogeny and adaptation
- Two distinct areas of evolutionary medicine
- The phylogenomic half of evolutionary medicine
- Homo sapiens phylogeny
- Tracing human origins
- TB in the New World from seals
- COVID-19 origins
- Selection for TB protection in cities
- The inability to digest milk as an adult
- Strep mutans and carbohydrates cause cavities
- Why natural selection left us vulnerable to disease
- Explaining disease vulnerability
- Why did natural selection leave us vulnerable?
- Explanations for vulnerability
- Mutations
- Apo E4
- Developmental variation
- Species-wide vulnerabilities
- Wrenching transitions: to bipedality
- Wrenching transitions: cognitive/social niche
- Schizophrenia from the transition to the cognitive-social niche
- Older alleles increase risk, newer alleles decrease risk
- Scurvy
- Why billions of years for complex organisms to emerge?
- Infection: we are vulnerable because…
- Antibiotic resistance
- Death from drug-resistant infections
- Take every pill in the bottle?
- Revised recommendation
- Cancer: why aren't we protected?
- Peto's Paradox proves strong selection against cancer
- Reproductive patterns are different now
- Cancer and somatic evolution
- Adaptive cancer therapy
- Cancer vs. aging: the telomere trade-off
- Atherosclerosis
- Atheroma
- Coronary disease in the Tsimane
- Obesity and diet
- Autoimmune diseases increasing
- C-section increases risks
- Multiple sclerosis
- Helminths protect against multiple sclerosis
- Why amyloid beta?
- Diametric diseases
- Painful symptoms
- Defenses vs. defects
- Panic disorder
- How loud a noise before you flee?
- The smoke detector principle
- Complex genetic diseases
- Highly heritable diseases are mostly caused by environments
- Myopia
- Cliff edge fitness functions
- Evolutionary medicine progress
- Evolution: a basic science for medicine
- EvMed teaching
- Evolutionary medicine programs
- Conclusion
Topics Covered
- What is evolutionary medicine
- Explaining traits
- Natural selection and disease vulnerability
- Cancer and natural protection
- Adaptation and maladaptation
- Wrenching transitions
- Defenses vs. defects
- The future of evolutionary medicine
Links
Series:
Categories:
Therapeutic Areas:
External Links
Talk Citation
Nesse, R. (2023, June 22). Evolutionary medicine [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 15, 2025, from https://doi.org/10.69645/HDXO4388.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Randolph Nesse has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Immunology & Inflammation
Transcript
Please wait while the transcript is being prepared...
0:00
Hello everyone and
welcome to this talk
providing an overview of
evolutionary medicine.
I'm Randy Nesse from
the University of Michigan
and Arizona State University,
and the editor of this
Henry Stewart Talks series
of over 50 talks about
evolutionary medicine.
It's not possible to do
justice to the field
at this point.
It's grown so fast and there are
so many interesting
developments.
But I will provide some
highlights that I hope will help
organize your attention to the
other talks in the series.
0:30
Evolutionary medicine
sounds like it's something
radical or alternative or
a new practice method.
It's none of those things.
It's just a basic science for
medicine like genetics
or physiology.
Evolutionary medicine
uses the basic science
of evolutionary biology
to better understand,
prevent, and treat disease.
You would think this would
have been done long ago.
But one of the very
surprising things that we're
going to discover
in this talk is
evolutionary biology has
basically been neglected
by medicine and a huge
opportunity therefore awaits.
1:03
This diagram shows
evolutionary biology
as the basic science,
medicine as the applied field
with evolutionary
medicine in between.
But those arrows are
significant also,
it's not a one-way street just
using basic science to medicine.
It's also the fact that
studying diseases offers
deep insights into the nature
of why biological systems fail,
which advances studies
in evolutionary biology.
1:28
The field has grown
enormously fast.
George Williams and I wrote
a paper grandly titled.
It was his idea with
the grand title there,
the Dawn of Darwinian
Medicine in 1991.
You can see the scholar
citations increasing
exponentially and they continue
to do so in recent years.
There's now a
scientific society,
the International Society for
Evolution, Medicine, and Public Health,
having its eighth annual
meeting this year;
an Oxford Press journal,
Evolution Medicine and Public
Health, it's open access.
EvMedEd is a series
of resources,
the Evolution of
Medicine Review is
a newsletter, and club
EvMedEd is a journal club
that meets regularly.
If you find all
this interesting,
you can go to
evmed.org and sign up
for newsletters and
other resources.
Henry Stewart Talks
has made a lot of
this possible and
growing faster.