• Cancer and Oncology
• 30 min
  1. The molecular basis of cancer metastasis: molecular mechanisms of epithelial-mesenchymal transition in tumor metastasis

  • Prof. Jing Yang
• 26 min
  2. The molecular basis of cancer metastasis: multi-step metastasis process and anti-metastasis therapeutic development

  • Prof. Jing Yang
• 28 min
  3. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours

  • Dr. Else Marit Inderberg
• 36 min
  4. Mode of action of T cells engineered with CAR or TCR for cancer treatment

  • Prof. Sebastian Kobold
• 37 min
  5. Immunotherapy: insights from advanced disease

  • Dr. Sara M. Tolaney
• 35 min
  6. Recent advances in the field of non-coding RNAs in cancer

  • Prof. George Calin
  • Dr. Maitri Shah
• 34 min
  7. How tumor-microenvironment interactions drive or inhibit metastasis

  • Prof. Isaac P. Witz
• 23 min
  8. A novel cancer therapy to stimulate oncogenic ERK signalling

  • Prof. Reiko Sugiura
• 37 min
  9. MRD-driven multiple myeloma treatment: next step forward

  • Prof. Ola Landgren
• 34 min
  10. The role of exosomes in multiple myeloma development & drug resistance

  • Prof. Eline Menu
• 29 min
  11. Germinal centre lymphomas: advances in diagnostic and therapeutic intervention

  • Dr. Koorosh Korfi
  • Prof. Jude Fitzgibbon
• 37 min
  12. Immunotherapy in lung cancer

  • Dr. Mark M. Awad
• 35 min
  13. Preservation of fertility in cancer patients: the impact of chemotherapy

  • Prof. Kutluk H. Oktay
• 41 min
  14. Preservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation

  • Prof. Kutluk H. Oktay
• 47 min
  15. Solution proposed to a 2000 year old problem in oncology

  • Dr. Michael Retsky
• Clinical Practice
• 36 min
  16. Stillbirth: diagnosis, investigation and aftercare

  • Prof. Alexander E. P. Heazell
• 30 min
  17. Analyzing the medical relevance of skin care trends

  • Prof. Zoe Draelos
• 42 min
  18. Genetic counseling: preconception, prenatal, perinatal

  • Prof. Aubrey Milunsky
• 26 min
  19. The past, present & future of ANA testing: history and challenges of ANA

  • Prof. Marvin J. Fritzler
• 33 min
  20. The past, present & future of ANA testing: changing bandwidth and future of ANA

  • Prof. Marvin J. Fritzler
• 40 min
  21. Modern management of rheumatoid arthritis - with a focus on biologic therapies

  • Prof. John Isaacs
• 33 min
  22. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 31 min
  23. Hemophilia A

  • Dr. Snejana Krassova
• 32 min
  24. Artificial intelligence in medicine: history & state of the art

  • Prof. John Fox
• 27 min
  25. Artificial intelligence in medicine: scaling & deployment of applications

  • Prof. John Fox
• 36 min
  26. Recent advances in diagnosis and interventions in ophthalmology

  • Dr. Rebecca Kaye
  • Prof. Andrew Lotery
• Gastroenterology
• 34 min
  27. Building implantable human liver tissue from pluripotent stem cells

  • Prof. David C. Hay
• 35 min
  28. Microbiome therapies to treat gastrointestinal diseases

  • Dr. Patricia Bloom
• 46 min
  29. Drug-induced liver injury: importance, epidemiology, and mechanisms of DILI

  • Prof. James H. Lewis
• 26 min
  30. Drug-induced liver injury: risk factors and drug development in DILI

  • Prof. James H. Lewis
• 39 min
  31. Drug-induced liver injury: HDS, diagnosing, treating and preventing DILI

  • Prof. James H. Lewis
• 46 min
  32. An update on the multiple faces of celiac disease

  • Prof. Aaron Lerner
• Immunology
• 56 min
  33. Drug allergy: new knowledge

  • Prof. Mariana C. Castells
• 32 min
  34. Biologics as a treatment strategy in food allergy

  • Prof. Sayantani B. Sindher
• 42 min
  35. B cells at the crossroads of autoimmune diseases

  • Dr. Xiang Lin
• 48 min
  36. Studying immune responses “one cell at a time”

  • Dr. Mir-Farzin Mashreghi
• 43 min
  37. Mathematical modeling in immunology

  • Prof. Ruy M. Ribeiro
• 18 min
  38. Therapeutic antibody development

  • Prof. Dr. Katja Hanack
• 25 min
  39. Understanding treatment coverage in mass drug administrations

  • Dr. Margaret Baker
• 39 min
  40. The thymus and T cell development: a primer

  • Prof. Georg Holländer
• 40 min
  41. The potential of CAR T cells for the treatment of autoimmune diseases

  • Dr. Marko Radic
• Infectious Diseases
• 36 min
  42. The Global Virus Network: collaboration to address pandemic and regional threats

  • Prof. Sten H. Vermund
• 28 min
  43. New concepts in the management of CAP: a focus on severe illness - treatment and therapies

  • Prof. Michael S. Niederman
• 24 min
  44. New concepts in the management of CAP: a focus on severe illness - MRSA and MDR pathogens

  • Prof. Michael S. Niederman
• 46 min
  45. CRISPR-based suppression drives for vector control

  • Prof. Andrea Crisanti
• 39 min
  46. HIV cure: harnessing innate and adaptive strategies

  • Prof. Luis Montaner
• Cardiovascular, Metabolism & Nutrition
• 29 min
  47. Cow’s milk allergy: the future

  • Dr. Carina Venter
• 17 min
  48. Cow's milk allergy: management

  • Dr. Carina Venter
• 50 min
  49. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 44 min
  50. X-linked hypophosphataemia: genetics, diagnosis and management

  • Prof. Thomas O. Carpenter
• 37 min
  51. What is new in type 1 diabetes?

  • Prof. Åke Lernmark
• 35 min
  52. Current concepts for the management of patients with osteoporosis

  • Dr. Michael Lewiecki
• 29 min
  53. Antibodies to control or prevent type 1 diabetes

  • Dr. Robert Hilbrands
• 38 min
  54. Peptide YY (PYY) in obesity and diabetes

  • Dr. Nigel Irwin
• Microbiology
• 39 min
  55. Vaccines and the fight against antimicrobial resistance 1

  • Dr. Annaliesa S. Anderson
• 40 min
  56. Vaccines and the fight against antimicrobial resistance 2

  • Dr. Annaliesa S. Anderson
• 30 min
  57. Vaccines as a weapon against antibiotic resistance

  • Dr. Pumtiwitt McCarthy
• 24 min
  58. PathoLive: pathogen detection while sequencing

  • Dr. Simon Tausch
• 37 min
  59. Translating microbiome research to clinics: trends, directions and challenges

  • Prof. Raj Eri
• 37 min
  60. Successes and failures with vaccines

  • Prof. Stanley Plotkin
• 30 min
  61. Immunology, the microbiome and future perspectives

  • Prof. Sheena Cruickshank
• 22 min
  62. Impact of the HPV vaccine programme – a changing landscape

  • Dr. Kevin Pollock
• Neurology and Neuroscience
• 48 min
  63. Advances in the diagnosis and treatment of tardive dyskinesia

  • Prof. Emeritus Stanley N. Caroff
• 31 min
  64. Cellular therapies for neurological Injuries: bioreactors, potency, and coagulation

  • Prof. Charles S. Cox, Jr.
• 57 min
  65. Cardiovascular involvement in Parkinson’s disease

  • Dr. David S. Goldstein
• 22 min
  66. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• 34 min
  67. Current thinking in pain medicine and some thoughts on back pain

  • Dr. Nick Hacking
• 27 min
  68. Bioelectronic medicine: immunomodulation by vagus nerve stimulation

  • Prof. Paul Peter Tak
• 31 min
  69. Developments & future directions in the management of chronic pain

  • Prof. Simon Haroutounian
• 41 min
  70. Deep Brain Stimulation (DBS) neuromodulation for Schizophrenia

  • Prof. Judith Gault
• 39 min
  71. Parkinson’s at 200 years: an update on Parkinson’s research in 2017

  • Prof. Patrick A. Lewis
• 43 min
  72. Alzheimer's disease: where are we up to?

  • Prof. John Hardy
• Pharmaceutical Sciences
• 38 min
  73. Pharmacokinetics, -dynamics and dosing considerations in children

  • Prof. Dr. Karel Allegaert
• 24 min
  74. Why in vitro permeation test – and not in vivo?

  • Prof. Howard Maibach
• 48 min
  75. The future of plasma-derived medicinal products (PDMP)

  • Dr. Daniele Focosi
• 37 min
  76. RNA therapeutics: clinical applications and methods of delivery

  • Prof. John P. Cooke
• 40 min
  77. Recent advances in the development of gene delivery technologies

  • Dr. Takis Athanasopoulos
• 32 min
  78. Preclinical translation of mesenchymal stem cell therapies

  • Dr. Peter Childs
• 20 min
  79. Modulating gene expression to treat diseases

  • Dr. Navneet Matharu
• 38 min
  80. Accelerating drug discovery with machine learning and AI

  • Dr. Olexandr Isayev
• 40 min
  81. AI and big data in drug discovery

  • Mr. Ed Addison
• 44 min
  82. Emerging big data in medicinal chemistry: promiscuity analysis as an example

  • Prof. Dr. Jürgen Bajorath
  • Dr. Ye Hu
• 49 min
  83. Binding kinetics in drug discovery

  • Dr. Rumin Zhang
• 49 min
  84. Modeling of antibody-drug conjugate pharmacokinetics

  • Dr. Dhaval K. Shah
• 35 min
  85. Antibody engineering: beginnings to bispecifics and beyond

  • Dr. Ian Wilkinson
• 51 min
  86. Current challenges in the design of antibody-drug conjugates

  • Prof. L. Nathan Tumey
• 27 min
  87. Inorganic nanostructured interfaces for therapeutic delivery

  • Prof. Tejal Desai
• 32 min
  88. Latest development in therapy-related autophagy research

  • Dr. Vignir Helgason
• Respiratory Diseases
• 29 min
  89. Respiratory syncytial virus vaccination

  • Prof. Peter Openshaw
• 22 min
  90. Advances in gene therapy for respiratory diseases 1

  • Prof. John F. Engelhardt
• 41 min
  91. Advances in gene therapy for respiratory diseases 2

  • Prof. John F. Engelhardt
• 37 min
  92. Asthma

  • Prof. William Busse
  • Dr. Amanda McIntyre
• 45 min
  93. New drugs for asthma

  • Prof. Peter Barnes
• 29 min
  94. CompEx asthma: a novel composite exacerbation endpoint

  • Dr. Carla A. Da Silva
• 42 min
  95. Updates in chronic obstructive pulmonary disease (COPD)

  • Dr. Omar S. Usmani

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The example project in this lecture
3. The complexity of the immune system
4. A systems immunological approach to dissect ongoing immune responses
5. How to use single cell technologies and systems immunology
6. Impaired type I IFN activity and inflammatory responses
7. Autoantibodies against type I IFNs
8. What other factors may account for severe cases?
9. The adaptive immune system reacting to SARS-CoV-2 over time
10. Chronic presence of plasmablasts in peripheral blood during severe COVID-19
11. 10x genomics technology
12. Transcriptomic clusters of activated B cells in COVID-19 patients
13. Activated B cells of severe COVID patients show no IFN-instruction later on
14. Cytokines are targeting immunoglobulin switch recombination to distinct classes
15. Antibody-isotypes report the cytokines driving the immune reaction
16. Is it an immune reaction against SARS-CoV-2?
17. IgA2 of COVID-19 patients is not specific for SARS-CoV-2 spike protein
18. If not SARS-CoV-2, what are the antibodies targeting?
19. None of the cloned BCRs recognize the SARS-CoV-2 spike or nucleoprotein
20. Severe COVID-19: TGF-β chronic immune reaction
21. Could TGF-β be to blame for delayed IFN response seen in severe COVID-19?
22. Early peak of serum TGF-β during severe COVID-19
23. A TGF-β response gene signature of NK cells is characteristic for severe COVID-19
24. TGF-β response is specific to severe COVID-19 and limits antiviral function of NK cells (1)
25. TGF-β response is specific to severe COVID-19 and limits antiviral function of NK cells (2)
26. Antiviral function of NK cells can be restored by anti-TGF-β
27. Which cells are expressing and responsible for the early peak of TGF-β
28. Lung cells from deceased COVID-19 patients express increased levels of TGF-β1 (1)
29. Lung cells from deceased COVID-19 patients express increased levels of TGF-β1 (2)
30. How does SARS-CoV-2 induce or mimic TGF-β responses in infected cells?
31. SARS-CoV-2 nucleoprotein (N) interacts with activated SMAD3
32. SARS-CoV-2 factors which promote TGF-β
33. Studying immune responses in severe COVID-19 at single cell level
34. Induction of a TGF-β response and the delayed IFN response in patients with severe COVID-19
35. Acknowledgements

Topics Covered

• Severe COVID-19
• Impaired type 1 interferon activity
• The adaptive immune system and COVID-19
• Chronic presence of plasmablasts
• 10x genomics technology
• Transcriptomic clusters
• IgA2
• IgG1
• IgM
• IgA1
• Spike protein and nucleoprotein
• TGF-β

Links

Series:

• The Immune System - Key Concepts and Questions
• Periodic Reports: Advances in Clinical Interventions and Research Platforms

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on January 31, 2023

Financial Disclosures

• Dr. Mir-Farzin Mashreghi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.