Registration for a live webinar on 'Precision medicine treatment for anticancer drug resistance' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- View the Talks
-
1. The deep history of life
- Prof. Andrew H. Knoll
-
2. The neutral and nearly neutral theories of molecular evolution 2
- Prof. Joseph P. Bielawski
-
3. The neutral and nearly neutral theories of molecular evolution 1
- Prof. Joseph P. Bielawski
-
4. The coalescent
- Prof. Peter Beerli
-
5. Evolution of drug resistance
- Dr. Pleuni Pennings
-
6. Trends in macroevolution
- Prof. Luke Harmon
-
7. Social evolution
- Prof. Dustin R. Rubenstein
-
8. Principles of phylogeography and landscape genetics
- Dr. Ryan Garrick
-
9. Evolutionary developmental biology
- Dr. Karen Sears
-
10. Biogeography: explaining the geographical distribution of organisms
- Prof. Alexandre Antonelli
-
11. Evolutionary case study: the genomics of speciation in Heliconius butterflies
- Prof. Adriana D. Briscoe
-
12. Human evolution
- Prof. Vagheesh Narasimhan
-
13. How do organisms evolve in response to global change?
- Prof. Erica Bree Rosenblum
-
14. Conservation genomics: adaptation and gene flow
- Prof. Jacob Höglund
-
15. Conservation genomics: genetic diversity and inbreeding
- Dr. Jacqueline Robinson
-
16. Evolution of agriculture: the origin of our food crops
- Dr. Mona Schreiber
-
17. Evolutionary medicine
- Prof. Stephen C. Stearns
Printable Handouts
Navigable Slide Index
- Introduction
- Darwin's predictions on human evolution
- Observing the extant great apes
- Evidence of morphological change from fossils
- The evolution of bipedalism
- The evolution of the human brain
- Early hominin fossils appear in Africa, Asia, Europe and the Near East
- Temporal existence of archaic human species
- Answering these questions via genetic sequencing
- Ancient DNA adds a time dimension to human genomic data
- A draft sequence of the Neanderthal genome
- Neanderthal ancestry in present day non-Africans
- The mysterious skull from Pestera Cu Oase
- Samples close to mixing time have close Neanderthal ancestors
- Ancient DNA from Sima De Los Huesos
- DNA evidence suggests that this population were early Neanderthals
- The discovery of the Denisovans
- Oceania individuals and Denisovans ancestry
- Admixture is ubiquitous in human history
- Multiple admixture events between Denisovans and Neanderthals
- Ancient DNA can be extracted from sediments
- Paleoproteomics, reaching deeper back into time
- A major genetic risk factor for severe Covid-19 is inherited from Neanderthals
- Investigating culture changes in the past 10,000 years
- Ancient DNA datasets across Eurasia
- Before farming, hunter-gatherers were highly genetically different
- Admixture occurs between farmers and hunter-gatherers
- The introduction of pastoralism in the north
- Similar mixture clines form between pastoralist populations
- Steppe pastoralist ancestry connects Europe and South Asia
- The parallel history of 2 subcontinents
- Understanding natural selection using admixture scans
- Signals of selection observed over the past 10,000 years
- LCT selection occurred thousands of years after the advent of dairy
- Light skinned pigmentation selection in Europe
- Natural selection in the present: allele frequencies by age group
- Natural selection in the present: alleles that affect offspring fathered/mothered
- Thank you
Topics Covered
- Human evolution from the fossil record
- Early hominid lineages in and out of Africa
- The genomic revolution
- The advent of ancient DNA
- Archaic admixture
- Sedimentary DNA
- Paleoproteomics
- Natural selection in humans in the past and present
Links
Series:
Categories:
External Links
Talk Citation
Narasimhan, V. (2022, July 31). Human evolution [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/QRCL2107.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Vagheesh Narasimhan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
This is Vagheesh Narasimhan.
I'm an assistant professor at
the University of Texas, Austin.
I'm going to talk to you
today about human evolution.
0:10
I'd like to begin by
saying that the study of
human evolution is something
that has fascinated
generations of scientists.
Charles Darwin, of course,
famously wrote a book
about human origins,
where he got many
basic things right,
including our relationship
with the great apes,
as well as the origin of
modern humans being in Africa.
0:30
One of the most obvious
ways to understand
human origins is to
compare ourselves
to our closest relatives,
the great apes.
Prior to molecular methods
looking at genomes,
this was carried out
primarily by examining
anatomical differences between
the great apes and us.
For example, we are
the only great apes
to have longer legs than arms
and we have additional
anatomical changes
in the pelvis and spine which
allow us to walk upright.
0:57
Fortunately, we're able to
look at these
differences in anatomy,
not just by comparing
ourselves to the great apes,
but over time by looking
at evidence from fossils.
Over the past 100 years
or so, large numbers
of hominin fossils
have been uncovered.
Hominids, as in
fossils that possess
particular characteristics
that differentiate
ourselves from the great apes,
however primitive these
characteristics might be.
These fossils provide
a way to look at
our evolutionary history
in steps of time.
Of course, this process
of drawing relationships
between fossils is not exact,
but it provides a record
of change over time
that we can use to understand
the evolutionary process.
1:36
One amazing thing that these
fossils allow us to do
is to look at skeletal
and anatomical changes
in structure that have evolved
over the past few million years.
In particular, it allows
us to look at changes
that allow for bipedalism,
the ability to walk
upright on two legs.
In this figure are a sequence
that we're observing in
the anatomy of the
hominid lineage
leading to ourselves.
As you can see,
the stability of these
hominids being able to
walk upright drastically
improves over time.