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1. Introduction
2. Is there an anti-inflammatory effect of estrogen?
3. The endothelium
4. Endothelial dysfunction
5. Leukocyte adhesion to the vascular wall
6. Functional and dysfunctional endothelium
7. Leukocyte-endothelial cell adhesion
8. Estrogen as determinant of cardiovascular risk
9. Epidemiological studies of estrogen effects
10. The estrogen conundrum
11. Coronary atherosclerosis in postmenopause
12. Women's health initiative design flaws
13. Mouse atherosclerosis study - lesion histology
14. Estrogen effects on the cardiovascular system
15. Rapid EC activation effects of estrogen
16. General model of estrogen effects
17. Endothelial nitric oxide synthase (eNOS)
18. Effect of 17-beta estradiol on NO release
19. Estrogen effect on cGMP and NO
20. Membranous and cytosolic estrogen receptors
21. Localization of estrogen receptor - flow cytometry
22. Estrogen receptors in human endothel
23. ER46 and ER66 structure
24. RT-PCR and immunoblot of ER46 and ER66
25. ERKO mouse cardiovascular studies
26. ERKO CV studies
27. Membrane translocation of ER46
28. Effect of estrogen on signaling sequence
29. AKT/protein kinase B: downstream effects
30. Estrogen induces AKT phosphorylation
31. Src kinases are involved with activation of NO
32. Estrogen effect on PI3 kinase activation
33. c-Src membrane targeting, ER46 localization
34. Model of estrogen induced NO release
35. c-Src-dependent E2-induced vasorelaxation
36. A complete model of E2 induced NO release
37. Endothelial homeostasis
38. Future questions
39. Kronos early estrogen prevention study
40. Comparisons within the KEEPS clinical trial
41. KEEPS centers and PIs
42. Summary
43. Acknowledgements

Topics Covered

• Endothelium
• Endothelial dysfunction
• Estrogen-mediated cardiovascular protection and leukocyte-endothelial cell adhesion
• Estrogen as a determinant of cardiovascular risk
• Effects of estrogen on the cardiovascular system
• Rapid EC activation effects of estrogen
• Effect of estradiol on NO release from human endothelial cells
• Estrogen receptor knockout (ERKO) mouse cardiovascular studies
• Palmitoylation is required for membrane translocation of ER46
• Akt/protein kinase B
• Endothelial homeostasis
• Kronos early estrogen prevention study

Links

Series:

• The World of Hormones

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Bender, J. (2007, December 1). Vascular cell signaling by membrane estrogen receptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/ILEI6950.
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Publication History

• Published on December 1, 2007

Financial Disclosures

• Prof. Jeffrey Bender has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.