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1. Introduction
2. Microbes everywhere
3. Different shapes of bacteria
4. Different sizes of bacteria
5. Genome data
6. Microbial genome sequencing
7. Microbial evolutionary genomics
8. Bacterial lifestyles
9. Topics
10. Genome size and number of genes
11. Minimal genome
12. Gene order comparison
13. Gene order in microbial genomes
14. Conservation of gene order in bacterial species
15. Mycoplasma species and gene order
16. Gene order conservation in closely related genera
17. Lack of gene order conservation
18. Protein length profile
19. PPD - proteome profile database
20. Obligatory genomes and associated diseases
21. Parasites possess small genomes
22. Genome compaction
23. Problems
24. Protein length distribution
25. Backbone genome and gene loss
26. More genomes and backbone genome
27. Different COG
28. COG category distribution
29. Common themes
30. Overlapping Genes (1)
31. Overlapping Genes (2)
32. Directions of overlap
33. Overlapping genes in nine genomes
34. Which genes overlap
35. Conclusion
36. Thank you

Topics Covered

• Host-pathogen interaction
• Microbial genomics
• Properties and functions of microbes: their genomes, protein coding, sequences and putative biochemical pathways
• The concept of the "universal" minimal genome
• Strategies used by obligatory intracellular parasites for genome reduction and survival
• The use of comparative genomics in understanding the concept of the "backbone genome"
• Differential gene loss and overlapping genes
• Drug targets

Links

Series:

• Using Bioinformatics in the Exploration of Genetic Diversity

Categories:

• Genetics & Epigenetics
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Kishore Sakharkar has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.