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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosures
- Hans Staden, 1552
- Bone pointing
- “Fight-or-flight response”
- Stressful situations leading to death in the modern era
- Myocytolysis or contraction band necrosis
- Myocytolysis
- Cardiovascular complications after stroke
- CV death after stroke
- Troponin T elevation
- Problems
- Links between voodoo death and SIHI
- Cohort creation
- Major Adverse Cardiovascular Events (MACE) at 1 year
- Incident heart disease after ischemic stroke (1)
- Incident heart disease after ischemic stroke (2)
- Incident heart disease after ischemic stroke (3)
- Potential explanations
- “Cell death factors”
- Rat model of selective insular stroke and atrial disease
- Rat model of right and left insular strokes
- Left atrial changes induced by insular strokes (1)
- Left atrial changes induced by insular strokes (2)
- Left atrial changes induced by insular strokes (3)
- Myocardiocyte death
- Myocardial inflammation in Takotsubo cardiomyopathy
- LA-PV border
- Differences between the distal LA and the LA-PV border
- Time course analysis (1)
- Time course analysis (2)
- Inflammatory markers
- Time course analysis (3)
- Pathophysiology
- Proposed model of insular stroke induced LA-injury
- Conclusion
- Thank you!
Topics Covered
- Cardiovascular complications after stroke
- Heart and brain relationship
- Autonomic nervous system
- Left atrial cardiopathy
- Myocardial inflammation
- Microvascular coronary endothelial dysfunction
- Left atrial fibrosis
- Major adverse cardiovascular events
- Post-stroke cardiac arrhythmias
- Atrial fibrillation
- Stroke-induced heart injury
- Post-stroke coronary events
- Stroke-induced myocardial infarction
Links
Series:
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Therapeutic Areas:
External Links
Talk Citation
Sposato, L.A. (2021, June 30). Stroke-induced heart injury [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/ELWH9620.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Neurology
Transcript
Please wait while the transcript is being prepared...
0:00
I am Luciano Sposato, stroke neurologist
and Head of the Stroke Program at London Health Sciences Center,
Western University London, Canada.
I will be talking about stroke induced heart injury.
0:14
These are my disclosures.
0:17
I will start talking about the story of Hans Staden,
who was on a Spanish expedition to Brazil when his ship wrecked.
It was captured by the Tupinambas.
A tribe ready known in Europe because of being cannibals.
He was smart enough to survive though,
and when he came back to Europe,
he was able to compile a narrative of his capture.
One of the most interesting aspects of his story is that he observed
that when people were sentenced by the so-called Medicine Man,
they died within a few days.
Death was apparently induced or triggered just by being sentenced by the Medicine Man.
0:54
Similar stories were brought from the Arunta Tribe in Australia,
where during the ceremony of bone pointing,
the wizard uttered curses in a low tone
and victims sickened and died within a month or so.
1:09
These stories inspired Dr. Walter Cannon to
develop the hypothesis or the theory about fight or flight response.
He thought that when humans or animals in general
faced stress for situations in which they are at risk,
they trigger a response of
sympathetic-adrenal system motivation that
leads to several other pathophysiological events,
including increased blood clotting or massive release
of adrenalin that at the end causes heart damage
he described as "voodoo death" based on the history of the stories
of people dying in these tribes just by being sentenced by the Medicine Man.