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Printable Handouts
Navigable Slide Index
- Introduction
- The hygiene hypothesis
- Immediate hypersensitivity = allergy
- Mast cells
- The structure of a mast cell
- Stained mast cells in connective tissue
- Immunoglobulin E and its receptors
- Immunoglobulin E (IgE) structure
- IgE binds to receptors on mast cells
- Signaling cascades triggered upon antigen binding to IgE
- Degranulation
- The process of mast cell degranulation
- Events during an allergic response
- Basophils
- Basophils from different domestic animals
- Eosinophils
- Eosinophils from different domestic animals
- Eosinophil structure
- Eosinophils activation
- Eosinophils functions
- Allergic diseases
- Mast cells mediate acute inflammation
- Anaphylaxis
- Anaphylaxis summary
- Allergic dermatitis
- The pathogenesis of atopic dermatitis
- A moist "hot spot" in a retriever
- An eosinophilic granuloma on the footpad of a cat
- The allergic response in the dermis
- Skin barrier dysfunction
- The diagnostic criteria for canine atopic dermatitis
- Foods
- Food allergies
- Inhalation allergies
- Inhaled allergens mechanisms
- Diagnosis of atopic dermatitis
- Intradermal skin tests
- Immunotherapy (allergy shots)
- Mechanisms of "allergy shots"
- Key points: animal allergies
- Acknowledgments
Topics Covered
- The process of mast cell degranulation and IgE involvement
- Allergic disease in animals
- Type 1 hypersensitivity
- Anaphylaxis
- The pathogenesis of allergic dermatitis
- Allergic dermatitis might not involve IgE
- Diagnosis and treatment of allergic dermatitis
- Allergy shots are the best long-term treatment
Links
Categories:
Therapeutic Areas:
Talk Citation
Tizard, I. (2021, March 30). Animal allergies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 5, 2024, from https://doi.org/10.69645/NHHF8207.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Immunology & Inflammation
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Ian Tizard and I am a professor of immunology at Texas A&M University.
My specific interests, and what I'm going to talk about today, are allergies in animals.
Because just as allergies have grown in importance in the human population,
they have also grown in importance in our pets and domestic animals.
One obvious question is:
why has this happened?
It appears that the answer is,
we're simply too clean.
0:38
The reason why we believe that allergies have
increased so dramatically in modern society,
is encapsulated in what is known as 'the hygiene hypothesis'.
This simply says, Western lifestyles have messed up the control of our immune system.
You've probably realized that our intestine is loaded
with millions or billions of bacteria,
and those bacteria signal to the immune system.
They release molecules that turn on the immune system,
molecules that determine what immune response we mount.
It appears that with our Western lifestyle,
the microbes in our intestine are sending the wrong message to our immune system.
As a result, our immune system is
(as it were) 'misbehaving',
and that misbehavior is exemplified by the growing prevalence of allergic diseases.
As I said, it happens not just in humans,
but also in our domestic pets.