The Eph receptor family

Published on October 1, 2007 Reviewed on May 6, 2017   36 min

Other Talks in the Category: Cell Biology

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The Eph Receptor Family, by Elena Pasquale from the Burnham Institute. The Eph receptors are divided into two groups,
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the EphA receptors and the EphB receptors. These receptors bind ligands which are called Ephrins and which are also membrane-associated. The EphA receptors preferentially bind the ephrin-A ligands which are GPI-linked molecules. The EphB receptors preferentially bind the ephrin-B ligands which are transmembrane molecules. With regard to the domain structure, the Eph receptors contain tyrosine kinase domain in their cytoplasmic region. This domain is linked to the membrane by juxtamembrane region and is followed on the carboxy-terminal side by SAM domain and the PDZ domain-binding site at the extreme carboxy-terminus. On the extracellular side, there are two fibronectin type three repeats, a cysteine-rich region and the ephrin-binding domain at the extreme amino-terminus. The extracellular domain on the ephrins is almost entirely occupied by the Eph receptor-binding domain. The ephrin-B ligands also have a short carboxy-terminal tail with a PDZ domain-binding site at the extreme carboxy-terminus. There are 10 EphA receptors,