Fundamentals of HIV biology

Published on April 29, 2020   32 min

A selection of talks on Clinical Practice

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Hello and welcome to the lecture on the fundamentals of HIV biology. My name is Viviana Simon. I'm a professor of microbiology and medicine at the Icahn School of Medicine in New York City. I'm delighted to review with you what we currently know about HIV/AIDS disease.
I divided the lecture into three parts. First, we will take a big picture view and discuss HIV epidemiology. Next, we will zoom in and look at what happens in the infected person. Lastly, we will close by discussing what HIV does at the cellular level. I promise you at the end of the lecture, you will have the answers to all those questions listed here on this slide.
I will use abbreviations in this lecture and I briefly want to review them with you. We will talk about viruses, HIV-1, HIV-2, which stands for human immunodeficiency virus type 1 or type 2. We will talk about simian immunodeficiency viruses, which are related to HIV-1 and HIV-2, but are found in non-human primates. From the host side, we will talk about AIDS, which stands for acquired immunodeficiency syndrome. The treatment for HIV is highly active antiretroviral therapy, abbreviated HAART. Throughout the talk, I might be saying HIV instead of HIV-1 for simplicity sake.
First big question, where do we find HIV infections?
Since the beginning of the epidemic 35 years ago, more than 70 million people have been infected globally with HIV. HIV infected people live all over the world. Currently, it's estimated that over 36 million men, women, and children live with HIV. So majority of infected people live in Sub-Saharan Africa or India, but HIV infected people are found all over the world and all five continents.