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This is Nicolas Bazan.
I am the head of the LSU,
Neuroscience Center of Excellence School of Medicine.
That is Louisiana State University Health in New Orleans,
Louisiana the United States.
I would be pleased to share with you an overview about "Photoreceptors Protection".
The emphasis of this presentation will be on the significance of lipid mediators,
specifically the docosanoids and elovanoids.
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I'll like to mention to begin with that,
I am named inventor of technologies, models and
compositional matter related to the presentation that I will be making.
The intellectual property had been assigned from
my university to a start-up company called Neuresto Therapeutics.
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The themes that I would like to develop are
nine aspects of this novel neuroprotective lipid mediators.
The point number 1 that I would like to develop is
the significance of omega-3 fatty acids
specifically of docosahexanoic acid for the photoreceptor cell fuctional integrity.
The second point is how the diet and the liver are involved in
the supply of this omega-3 fatty acid docosahexaenoic acid to photoreceptor cells.
Then the third aspect that I would like to develop is a unique retention specificity,
of this DHA or docosahexaenoic acid specifically
mediated by a protein receptor called adiponectin receptor 1.
The fourth aspect is the biosynthesis of
the docosanoids and I will be talking specifically about neuroprotectin D1.
The fifth aspect is how neuroprotectin D1 that I would be referring to as NPD1
induces protective microglial cells
to modulate neural inflammatory signaling in the retina.
The sixth theme is
how NPD1 modulates inflammatory transcription to
confront homeostatic disruptions in the retinal pigment epithelial cell.
The point number seven, is the biosynthesis of the elovanoids.
The elovanoids are newly discovered lipid mediators that are necessary
for the retinal pigment epithelial cell integrity to sustain photoreceptor function.
Then the final point will be to talk about the long loop for
the supply and short loop for conservation of retention of docosahexaenoic acid,
and other molecules in the photoreceptor cell.
At the very end, I would like to provide a summary and conclusions.
