• Cellular Mechanisms of Mitochondrial Biogenesis in Health
• 23 min
  1. Nuclear control of electron transport chain gene expression

  • Dr. Glenn C. Rowe
• 48 min
  2. Regulation of mitochondrial biogenesis by transcriptional coactivators and estrogen-related receptor alpha

  • Dr. Anastasia Kralli
• 17 min
  3. Protein import into mitochondria

  • Dr. Trevor Lithgow
• 39 min
  4. Mitochondrial phospholipid synthesis and incorporation

  • Prof. Grant Hatch
• 23 min
  5. Mitochondrial DNA replication and transcription

  • Prof. Julio Montoya
• 37 min
  6. Mitochondrial production of reactive oxygen species 1

  • Prof. Martin Brand
• 22 min
  7. Mitochondrial production of reactive oxygen species 2

  • Prof. Martin Brand
• 35 min
  8. Mitophagy - the degradation of dysfunctional organelles

  • Dr. Anna Vainshtein
• Mitochondrial Biogenesis in Physiological Conditions
• 21 min
  9. Thyroid hormone and mitochondrial biogenesis

  • Dr. Joachim Weitzel
• 28 min
  10. Exercise-induced mitochondrial biogenesis in muscle 1

  • Prof. David Hood
• 37 min
  11. Exercise-induced mitochondrial biogenesis in muscle 2

  • Prof. David Hood
• Mitochondrial Biogenesis in Aging and Disease
• 33 min
  12. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 59 min
  13. Exercise and nutrition in mitochondrial disorders

  • Prof. Mark Tarnopolsky
• 42 min
  14. Mitochondrial disorders and neurodegeneration

  • Dr. Jan-Willem Taanman
• 33 min
  15. Reprogramming oxidative phosphorylation in cancer

  • Prof. José Cuezva
• 44 min
  16. Possible roles of mitochondrial biogenesis in aging

  • Dr. Aubrey de Grey
• 31 min
  17. Mitochondria in reproduction and fertility: mitochondria and gametes 1

  • Prof. Pascale May Panloup
• 30 min
  18. Mitochondria in reproduction and fertility: mitochondria and embryo 2

  • Prof. Pascale May Panloup
• 35 min
  19. Mitochondrial morphology and ultrastructure in skeletal muscle

  • Prof. Martin Picard
• 19 min
  20. Improving mitochondrial phenotypes with pharmaceuticals

  • Prof. Christopher Perry
• Mitochondria, Cell Signaling and Apoptosis
• 42 min
  21. Mitochondrial permeability transition

  • Prof. John Lemasters
• 47 min
  22. Pathways of apoptosis in muscle 1

  • Prof. Stephen E. Alway
• 42 min
  23. Pathways of apoptosis in muscle 2

  • Prof. Stephen E. Alway
• 21 min
  24. Controlling mitochondrial reactive oxygen species production for cell signaling 1

  • Dr. Ryan J. Mailloux
• 32 min
  25. Controlling mitochondrial reactive oxygen species production for cell signaling 2

  • Dr. Ryan J. Mailloux
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  26. Reactive oxygen species and myocardial apoptosis

  • Dr. Zhi-Qing Zhao
• 34 min
  27. Mitochondrial biogenesis as a result of exercise

  • Dr. Darrell Neufer
• 30 min
  28. Mechanisms of mitochondrial fusion and fission

  • Dr. Luca Scorrano
• 30 min
  29. Mitochondrial heterogeneity in cells

  • Dr. Tony Collins
• 40 min
  30. Mitochondrial diseases: an update

  • Prof. Salvatore DiMauro
• 41 min
  31. Calcium signaling and mitochondrial function

  • Prof. David Nicholls
• 35 min
  32. Mitochondrial biogenesis during gametogenesis and embryonic development

  • Prof. Pascal Reynier
• 33 min
  33. Mitochondrial complex assembly

  • Dr. Leo Nijtmans
• 33 min
  34. Evolutionary and developmental variation in muscle mitochondrial content

  • Prof. Christopher Moyes
• 33 min
  35. Muscle mitochondrial function and biogenesis with aging

  • Dr. Russell Hepple
• 23 min
  36. The mitochondrial pathway in apoptosis

  • Prof. Douglas Green
• 40 min
  37. Nuclear control of respiratory chain expression by transcriptional activators and coactivators

  • Prof. Richard Scarpulla
• 38 min
  38. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 43 min
  39. Respiration, reactive oxygen species and uncoupling proteins

  • Prof. Martin Brand

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Mitochondrial disorders and neurodegeneration (1)
3. Mitochondria- essential eukaryotic organelles (1)
4. Mitochondria- essential eukaryotic organelles (2)
5. Mitochondria- essential eukaryotic organelles (3)
6. Mitochondrial DNA (mtDNA)
7. Mitochondrial proteins
8. Bioenergetic pathways
9. The mitochondrial OXPHOS enzyme system
10. The mitochondrial OXPHOS enzyme complexes
11. The L and H strands
12. The mtDNA D-loop
13. Replication of mtDNA
14. BrdU detects DNA replicating DNA
15. mtDNA replication is independent of the cell cycle
16. Initiation of mtDNA replication
17. mtDNA shows maternal inheritance
18. Maternal inheritance of mtDNA molecular basis
19. Mitochondrial disorders and neurodegeneration (2)
20. mtDNA mutations (1)
21. mtDNA mutations (2)
22. The m.3243A>G mtDNA point mutation (1)
23. The m.3243A>G mtDNA point mutation (2)
24. The m.3243A>G mtDNA point mutation (3)
25. Mutations result in a decrease of ATP production
26. mtDNA mutations increrase ROS production
27. mtDNA point mutations show maternal inheritance
28. ART prevent transmission of mtDNA diseases (1)
29. ART prevent transmission of mtDNA diseases (2)
30. Mitochondrial disorders and neurodegeneration (3)
31. Nuclear gene defects in mitochondrial diseases (1)
32. Nuclear gene mutations & defects of mtDNA (1)
33. Nuclear gene mutations & defects of mtDNA (2)
34. Alpers’ disease caused by POLG mutations
35. Nuclear gene mutations & defects of mtDNA (3)
36. Defects of mt deoxynucleotide synthesis
37. BrdU incorporation into replicating DNA
38. Southern blot analysis of quiescent fibroblasts
39. Nuclear gene defects in mitochondrial diseases (2)
40. Friedreich’s ataxia – clinical hallmarks
41. Friedreich’s ataxia – pathogenesis
42. Nuclear gene defects in mitochondrial diseases (3)
43. Hereditary spastic paraplegia – clinical hallmarks
44. Hereditary spastic paraplegia – pathogenesis
45. Nuclear gene defects in mitochondrial diseases (4)
46. Nuclear gene defects in mitochondrial diseases (5)
47. Mitochondrial fission and fusion
48. Nuclear gene defects in mitochondrial diseases (6)
49. Parkinson’s disease – clinical hallmarks
50. Parkinson’s disease – pathological hallmarks
51. Parkinson’s disease – pathogenesis
52. Induction of mitophagy by PINK1 and Parkin
53. Mitochondrial disorders and neurodegeneration (4)

Topics Covered

• Mitochondrial structure and function
• Oxidative phosphorylation
• Mitochondrial DNA (mtDNA) structure, replication and maternal inheritance
• Diseases caused by mutations in mtDNA and therapy
• Diseases caused by mutations in nuclear genes coding for mitochondrial proteins

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on July 31, 2019

Financial Disclosures

• Dr. Jan-Willem Taanman has received consulting fees/honoraria from Novintum Biosciences Ltd., royalties from Abcam, and research support from The Michael J Fox Foundation.