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Structural and mechanistic insights into the neurotensin receptor

Published on July 31, 2019   55 min

Other Talks in the Series: G Protein-Coupled Receptors (GPCRs) signaling in health and disease

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My name is Reinhard Grisshammer. I am at the National Cancer Institute, at the National Institutes of Health in Bethesda, Maryland. The title of my talk is structural and mechanistic insights into the neurotensin receptor.
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The outline of my talk is as follows; I will give a brief introduction into GPCRs, G protein-coupled receptors and the neurotensin NTSR1. Then, I will talk about conformational thermostabilization, which is a technique to make proteins more amenable for crystallization. Then, I will present four neurotensin receptors structures. The first one is called NTSR1-GW5, which has an active-like conformation and provides insight into the neurotensin peptide binding mode. Two more structures called NTSR1-ELF and LF provide insight into the structural prerequisites of G protein activation. The last structure is of a construct called EL which shows constitutive activity, where we can learn about the structural features of a constitutively active receptor. In the end, I will summarize constitutive and agonist-induced signaling of the neurotensin receptor NTSR1.
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Structural and mechanistic insights into the neurotensin receptor

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