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Printable Handouts
Navigable Slide Index
- Introduction
- The GPCR superfamily
- The GPCR superfamily (GRAFS)
- Classification of the GPCR superfamily
- Structural determinants of GPCR classes
- GPCRs usually sense soluble compounds
- Adhesion GPCRs engage ligands
- Molecular layout of adhesion GPCRs
- Molecular layout of adhesion GPCRs (subfamilies)
- Questions on adhesion-type GPCRs (Perception)
- Adhesion GPCR & mechanosensory neurons
- Electrical activity is reduced upon dCirl removal
- Mechanical stimulation in neurons
- Spiking activity is reduced upon dCirl removal
- dCirl amplifies the receptor potential in neurons
- Receptor potential amplification & cAMP levels (1)
- Receptor potential amplification & cAMP levels (2)
- dCirl enhances sensitivity and contrast
- Adhesion GPCRs in mechanical contexts
- Questions on adhesion-type GPCRs (Signaling)
- GAIN-7TM domain couple & receptor activity (1)
- GAIN-7TM domain couple & receptor activity (2)
- Adhesion GPCRs & tethered agonist (1)
- Adhesion GPCRs & tethered agonist (2)
- Stimulation of adhesion GPCR tethered agonism
- Questions on adhesion-type GPCRs (Effects)
- Adhesion GPCRs & tissue polarity
- Flamingo governs planar cell polarity in flies
- Flamingo in flies & mammals
- Latrophilins/ADGRL & tissue polarity
- Latrophilins/ADGRL & tissue polarity (WT)
- Latrophilins/ADGRL & tissue polarity (KO)
- GPR56/ADGRG1 controls cortex architecture
- GPR126/ADGRG6 regulates Schwann cells
- Summary
- Acknowledgements
- References
Topics Covered
- Introduction into the adhesion GPCR family
- Molecular layout of adhesion GPCRs
- Adhesion GPCRs as putative mechanosensors
- Models on adhesion GPCR activation and signaling
- Developmental roles of adhesion GPCRs in the nervous system
- Adhesion GPCR dysfunction in neuropsychiatric diseases
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Talk Citation
Langenhan, T. (2019, May 16). Adhesion GPCRs in nervous system development and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/KRPP2603.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Tobias Langenhan, Info on Slide 88 : “Commercial/Financial matters disclosed are: Throughout the years T.L. has been generously supported by grants from the Wellcome Trust and the Deutsche Forschungsgemeinschaft (LA 2861/1-1, /4-1, /4-2, /5-1, /5-2, /6-1, /6-2, /7-1; SFB1047/A05; TRR166/C03), mainly in projects P01 and P03 of the DFG Research Unit ‘Adhesion GPCR Signaling’ (FOR 2149, www.adhesiongpcr.de)”
Other Talks in the Series: G Protein-Coupled Receptors (GPCRs) Signaling in Health and Disease
Transcript
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0:00
Hello, everybody, my name is Tobias Langenham,
and I'm a professor of Biochemistry,
at the Rudolf Schönheimer Institute of Biochemistry at Leipzig University in Germany.
Today, I'd like to introduce "Adhesion G-Protein-Coupled-Receptors,
and their Multiple Roles in Nervous System Development and Disease".
0:22
First, I would like to introduce the superfamily of G-protein-coupled receptors.
The surface molecules are mounted on the edges of many cells in our bodies,
and they amount to a massive battery of genes
stored in the genomes of actually all animals including humans.
For example, the human genome amounts and accounts more than 700 different GPCR genes.
GPCRs are implicated in multiple positions within our bodily functions.
For example, sensory systems that allow us
to smell compounds or to see things through our eyes.
They are also involved into feedback loops that are controlled,
for example, by hormones.
The GPCR superfamily can be divided according to different classification schemes.
In the slide, you can see a subdivision that is very popular,
which is termed GRAFS classification.
1:27
The GRAFS classification divides the GPCR superfamily into five different classes.
1:35
That is, the Glutamate receptors, Rhodopsin- like receptors,
Adhesion GPCRs, Frizzled/Taste2 receptors, Secretin receptors.
These different families within this GPCR superfamily contain different numbers of genes.
As you can see, rhodopsin-like GPCRs by far
outnumber all the other GPCR families with over 600 different genes.
However, the next largest group is adhesion GPCRs that are depicted here in the middle,
with over 30 different genes in the mammalian genomes.
In the slide, you can see some of the structural hallmarks that are