Registration for a live webinar on 'Chronic inflammation, immune cell trafficking and anti-trafficking agents' is now open.See webinar details
Adhesion GPCRs in nervous system development and disease
Published on May 16, 2019 36 min
Other Talks in the Series: G Protein-Coupled Receptors (GPCRs) signaling in health and disease
Pre-coupling of receptor oligomers and signaling molecules
- Dr. Sergi Ferré
- National Institute on Drug Abuse, USA
Novel approaches to treating symptoms and slowing the progress of neurodegenerative diseases
- Prof. Andrew B. Tobin
- University of Glasgow, UK
What can we learn from conformational profiling of GPCRs?
- Prof. Terry Hébert
- McGill University, Canada
Drugging conformational states of GPCRs
- Prof. Dr. Peter Kolb
- Philipps-Universität Marburg, Germany
Extracellular domain structures from calcium-sensing and GABA(B) receptors
- Dr. Qing R. Fan
- Columbia University, USA
Biology and structure of arrestin proteins
- Prof. Vsevolod V. Gurevich
- Vanderbilt University, USA
Hello, everybody, my name is Tobias Langenham, and I'm a professor of Biochemistry, at the Rudolf Schönheimer Institute of Biochemistry at Leipzig University in Germany. Today, I'd like to introduce "Adhesion G-Protein-Coupled-Receptors, and their Multiple Roles in Nervous System Development and Disease".
First, I would like to introduce the superfamily of G-protein-coupled receptors. The surface molecules are mounted on the edges of many cells in our bodies, and they amount to a massive battery of genes stored in the genomes of actually all animals including humans. For example, the human genome amounts and accounts more than 700 different GPCR genes. GPCRs are implicated in multiple positions within our bodily functions. For example, sensory systems that allow us to smell compounds or to see things through our eyes. They are also involved into feedback loops that are controlled, for example, by hormones. The GPCR superfamily can be divided according to different classification schemes. In the slide, you can see a subdivision that is very popular, which is termed GRAFS classification.
The GRAFS classification divides the GPCR superfamily into five different classes.
That is, the Glutamate receptors, Rhodopsin- like receptors, Adhesion GPCRs, Frizzled/Taste2 receptors, Secretin receptors. These different families within this GPCR superfamily contain different numbers of genes. As you can see, rhodopsin-like GPCRs by far outnumber all the other GPCR families with over 600 different genes. However, the next largest group is adhesion GPCRs that are depicted here in the middle, with over 30 different genes in the mammalian genomes. In the slide, you can see some of the structural hallmarks that are