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Printable Handouts
Navigable Slide Index
- Introduction
- The author
- Vitamin E structure: the different tocopherols
- Antioxidants with different biological functions
- The discovery of vitamin E
- The antioxidant function of vitamin E
- Recycling of vitamin E
- Problems of interpretation
- Tocopherol transfer protein (TTP)
- Unique uptake of alpha-tocopherol
- Inhibition of protein kinase C by tocopherol
- Ed Fisher: discovery of protein phosphorylation
- Nishizuka and protein kinase C
- PKC inhibition by different tocopherols
- Phosphatase activation and PKC inhibition
- Different effects of alpha and beta tocopherols
- Inhibition of NADPH-oxidase assembly
- Inhibition of CD36 gene transcription
- Uptake of oxidized LDL is inhibited by tocopherol
- A number of genes are regulated by tocopherol
- Structure of tocopherol associated protein (TAP)
- Specificity of alpha-tocopherol binding to TAP
- TAP has GTPase activity
- Tocopherol and PI3 kinase
- The PI3 kinase and PKC regulation system
- Protection of vitamin against radicals
- A scheme of molecular events in atherogenesis
- The contradictory results of population studies
- Protection of tocopherol against cancer
- Several pathologies are prevented by vitamin E
- Vitamin E in animal studies
- Tocopheryl phosphate is a natural molecule
- Tocopheryl phosphate is synthesized in cells
- No cytotoxicity of tocopheryl phosphate
- Tocopheryl phosphate and atherogenesis
- Inhibition of superoxide production
- Inhibition of CD36 expression
- Tocopheryl phosphate inhibits cell proliferation
- Tocopheryl phosphate conversion to tocopherol
- Tocopherol uptake by cells
- The structure of glybenclamide
- Glybenclamide and tocopherylphosphate uptake
- Effect of glybenclamide on cell proliferation
- Molecular effects of tocopheryl phosphate
- Diet TP is not converted to tocopherol
- Tocopheryl phosphate vs. tocopheryl acetate
- Tocopherol and tocopheryl phosphate action
- Thank you
Topics Covered
- Vitamin E or tocopherol's physiological molecular mechanism helps to understand protection against disease
- Not an antioxidant or free radical quencher, they perform cell signaling by affecting protein phosphorylation (for instance protein kinase C and PI3 kinase)
- They can be phosphorylated to more potent species, the tocopheryl phosphates
- Tocopheryl phosphates protect, in animal models against atherosclerosis
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Talk Citation
Azzi, A. (2017, October 21). Cell signaling by vitamin E [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/FAAC7972.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Angelo Azzi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.