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- General Virology
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1. Principles of virology
- Prof. Vincent Racaniello
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2. The type I interferon system and viruses
- Dr. Adolfo Garcia-Sastre
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3. Immune responses to viruses
- Prof. Paul Klenerman
- Emerging Pathogens
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4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide
- Dr. Marietjie Venter
- Mrs. Orienka Hellferscee
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5. Emerging respiratory viruses - discoveries between 2001 and 2005
- Prof. Ron Fouchier
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6. Usage of vaccines and therapeutics in public health emergencies 1
- Prof. Gary Kobinger
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7. Usage of vaccines and therapeutics in public health emergencies 2
- Prof. Gary Kobinger
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8. Influenza virus pandemics: past and future
- Prof. Peter Palese
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9. SARS-CoV and other emerging coronaviruses
- Prof. Ralph Baric
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10. Dengue, Zika and Chickungunya viruses
- Prof. Ana Fernandez-Sesma
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11. Paramyxoviruses: biology & pathogenesis
- Prof. Benhur Lee
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12. Antiviral drugs (non-HIV)
- Prof. Megan Shaw
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13. Biodefense challenges
- Dr. David Franz
- Important Pathogens and their Diseases
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14. Natural history and pathogenesis of herpes virus infections
- Prof. Richard Whitley
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15. Cytomegalovirus biology
- Prof. Domenico Tortorella
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16. Hepatitis C virus: discovery, cure and protection
- Dr. Matthew Evans
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17. Fundamentals of HIV biology
- Prof. Viviana Simon
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18. Measles
- Prof. Diane E. Griffin
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19. Monkeypox virus, vaccines, and therapeutics
- Prof. Rachel Roper
- New Frontiers
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22. Viruses as anticancer weapons
- Prof. Roberto Cattaneo
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23. Novel approaches to diagnosis of viral infections
- Prof. W. Ian Lipkin
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24. The Global Virus Network: collaboration to address pandemic and regional threats
- Prof. Sten H. Vermund
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25. Elite controllers of HIV: from discovery to future therapies
- Prof. Bruce Walker
- Archived Lectures *These may not cover the latest advances in the field
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26. Principles of virology I
- Prof. Richard Condit
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27. Principles of virology II
- Prof. Richard Condit
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28. Complex DNA viruses: herpes virus
- Dr. John Blaho
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29. Adeno-associated viruses (AAV)
- Prof. Kenneth Berns
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30. Poxviruses: smallpox (variola), vaccinia and monkeypox
- Prof. Paula Traktman
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31. Can HPV testing be the sole primary cervical screening modality?
- Prof. Jack Cuzick
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32. From viruses to oncolytics
- Prof. Roberto Cattaneo
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33. Non HIV antivirals
- Prof. Mary Klotman
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34. Gastroenteritis viruses
- Prof. Mary Estes
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35. Biodefense challenges
- Dr. Connie Schmaljohn
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37. The past, present and future of vaccination
- Prof. Stanley Plotkin
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38. Filoviruses
- Dr. Christopher Basler
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39. Bunyaviruses
- Prof. Richard Elliott
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40. The immunobiology of HIV
- Prof. Norman Letvin
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41. Hepatitis C and HCV
- Prof. Stanley Lemon
Printable Handouts
Navigable Slide Index
- Introduction
- Biodefense Challenges
- Lecture outline
- I knew an “ole bioweaponeer”…
- Scenario: attack on NYC subway system (1)
- Scenario: attack on NYC subway system (2)
- Scenario: attack on NYC subway system (3)
- U.S. BW trials in San Francisco Bay (1)
- U.S. BW trials in San Francisco Bay (2)
- Learning biosafety while developing bioweapons
- Nature is still more powerful
- Natural & man-made infectious disease
- Criteria for potential BW agents
- A more recent position
- The pathogens are ubiquitous
- But, the presentation is critical
- Messelsen on the misuse of technologies
- Facilitating technologies and their global availability
- The academic community takes risks seriously
- Global travel and transport
- And then everything changed…
- The science community tried to help
- The concept of “dual use” research
- Fink report conclusions
- NSABB reports
- The infectious disease community
- The Dingell-Stupak letter
- WMD Commission of 2008
- Mammalian transmissible A/H5N1
- A tendency to regulate…
- More new regulation…
- Super strains of infectious diseases
- Actions by a few impact the many
- And just as things were settling down…
- What can we do?
- Over-regulation of the enterprise
- So where does that leave us?
- Proposal: lead with public health
- Public health infrastructure
- Aware law enforcement and intelligence
- Eight characteristics of excellent leadership
- Strong international collaborations
- In our own labs
- Internationally lead with public health
- Health engagement for global BioSecurity
- A robust tech base and SMEs
Topics Covered
- Understanding biodefense history, threats and preparedness
- Brief history of modern biological warfare programs
- Development of the principles of biosafety
- Relationship to emerging infectious disease
- Impact of the biotech revolution
- Dual-use research
- The anthrax letters and safety lapses
- Enhanced regulation of infectious disease research
- Education and awareness for safety and security
- The public health approach to preparedness
- Leadership and healthy laboratory organizational cultures
- Global science collaboration
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Franz, D. (2018, August 30). Biodefense challenges [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/ZFYR1049.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. David Franz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Infectious Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Dave Franz.
I'm a Former Commander of
the US Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland.
I served the last 11 years of my military career at that institute.
It's often called USAMRIID.
During the next 45 minutes,
I will discuss some of the challenges that we face
globally with regard to the misuse of biology.
0:28
When I began working in this field,
before the end of the Cold War,
we were focused on threats from the former Soviet Union.
We expected our military forces to face
aerosolized microbes in the folder gap in European war,
or even worse, we might have faced attacks of
smallpox virus or plague bacilli on our homeland.
Since the end of the Cold War and with the advent of the biotechnology revolution,
the interest in and concern regarding
the worldwide threats of terrorism have changed significantly.
But the science has changed even more.
1:10
I will provide a short history of Cold War biological weapons programs.
Compare natural and intentional disease impact on society.
Discuss the characteristics of threat agents.
Talk briefly about new technologies and how they complicate the old challenges.
Speak about our recent experience with biosecurity in the United States.
Describe the complexities and interaction.
Safety, security, and progress in our laboratories,
and the importance of balance rational regulation of science.
Finally, present some thoughts on the way ahead.