Registration for a live webinar on 'The role of T cells in COVID from asymptomatic to severe outcomes' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
-
2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
-
4. The SODs
- Prof. Daret St. Clair
-
5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
-
6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
-
7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
-
8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
-
9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
-
11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
-
12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
-
13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
-
14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
-
15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
-
16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
-
17. Oxidative stress in aging
- Dr. Jose Vina
-
18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
-
19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
-
20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
-
21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
-
22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
-
24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Mitochondria and reactive oxygen species
- Oxygen chemistry
- Reactive oxygen species chemistry
- ROS mediated cellular damage
- Reactive oxygen species in disease
- Antioxidant defenses
- Overview of mitochondrial ROS generation (1)
- Mitochondria structure and topology
- Mitochondria: a cellular source of oxygen radicals
- Respiratory complexes
- Mitochondria bioenergetics
- ROS generation by mitochondria - overview
- ROS generation by mitochondria - chemistry
- ROS generation by mitochondria
- Sites and mechanism of ROS generation
- Complex I
- Complex II
- Complex III
- Ubisemiquinone
- Complex IV
- Antioxidant defenses - superoxide dismutase
- Antioxidant defenses - mitochondrial GSH
- Superoxide generated towards the matrix
- Superoxide generated towards the IM space
- Superoxide anion diffusion control through VDAC
- VDAC control the release of superoxide to cytosol
- Topology of ROS generation by mitochondria
- Literature of topology of superoxide release
- Mitochondria - a source of oxygen radicals
- Overview of mitochondrial ROS generation (2)
- Methods to measure hydrogen peroxide release
- Use of DCFH to measure hydrogen peroxide
- Methods to measure superoxide release
- Measurement of superoxide using hydroethidine
- Overview of mitochondrial ROS generation (3)
- Regulation of mitochondrial ROS generation (1)
- Respiration rate by the electron transport chain (1)
- UCP as a mitochondrial ROS generation regulator
- Respiration rate by the electron transport chain (2)
- Respiration rate by the electron transport chain (3)
- Regulation of mitochondrial ROS generation (2)
- Mitochondrial GSH
- GSH depletion and complex I H2O2 production
- Effect of GSH depletion on H2O2 production
- Regulation of mitochondrial ROS generation (3)
- Ceramides
- Ceramide and mitochondrial ROS generation
- Regulation of mitochondrial ROS generation (4)
- NO - a regulator of mitochondrial function
- Inhibition of mitochondrial respiration by NO
- Inhibition of cytochrome oxidase by NO
- Formation of peroxynitrite
- Biphasic effect of NO on H2O2 production
- Reactive oxygen and nitrogen species generation
- Regulation of mitochondrial ROS generation (5)
- Post translational protein modifications
- Mitochondrial post translational modifications
- S-glutathionylation of aconitase decreases activity
- Post translational modification of complex I
- Modifying the cell's redox status
- Post translational modification by ROS and RNS
- Signaling molecules and MAPK regulation
- Summary
- Acknowledgements
Topics Covered
- Oxygen chemistry
- Reactive oxygen species chemistry and in disease
- Antioxidants defenses
- Mitochondria structure and topology
- Mitochondria bioenergetics
- Sites and mechanisms
- Superoxide dismutase
- Mitochondrial GSH
- Superoxide generation
- Voltage-dependent anion channels
- Methods to measure reactive oxygen species
- Regulation of mitochondrial reactive oxygen species generation
- Rate of respiration by the electron transport chain
- Ceramide
- Nitric oxide
- Post-translational modification
Talk Citation
Cadenas, E. and Han, D. (2007, November 1). Generation of reactive oxygen species by mitochondria [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/378/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Enrique Cadenas has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Derick Han has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.