Metabolomics flux on the genome scale

Published on April 30, 2018   29 min

Other Talks in the Series: Bioinformatics for Metabolomics

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Hi. I am Marta Cascante. I am Professor of Biochemistry and Molecular Biology at the Department of Biochemistry and Molecular Medicine at the University of Barcelona. I study molecular basis of integrating experimental and computational approach, the framework of system biology and systems medicine, with a focus on metabolic adaptations accompanying essential cell phase and pathological alterations associated with multi-factorial disease, such as cancer. Long-term goal of our research is to develop new therapies and new bio-markers. Hi I'm Igor Marin. I'm a Computational Biologist, and I'm currently a Postdoctoral Researcher at the Institute of Environmental Assessment and Water Research run by the Spanish Research Council. My specific interest lies in the section of computational method and self systems. More specifically, my research is focused on developing and applying methods based on computational modeling to study the metabolic and signaling mechanics underlying cellular disorders. So, today we are going to introduce computational modeling and metabolic flux concepts in the context of systems biology approach.
This stuff is divided in four parts. First, we will briefly explain the main concepts that has been explained in the previous talk. Next, we will introduce the constraint-based modeling approach. In the third part, we will talk about the kinetic modeling approach. Finally, we will present some application and examples of computational modeling. In our previous talk, we introduced the concept of computational modeling in the framework of systems biology.