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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Smallpox eradication
- Most vaccines are live-attenuated
- Generation of effective vaccines
- Cancer therapy with viruses: the origins
- Natural oncolytic properties of viruses
- Efficient tumor access
- New anticancer weapons
- 2015: first FDA-approved oncolytic virus
- Imlygic: recommended dose and schedule
- “Oncolytic virus” May 2017: 79 clinical trials
- Examples of current clinical trials - 9 virus families
- Added oncolytic properties
- Targeting
- Arming strategies that induce bystander cell killing
- Shielding from neutralizing antibodies
- Adding genes for arming or monitoring
- Imaging in 4D (3D + time)
- 3D - live imaging by tomography (SPECT/CT)
- 4D: correlating replication with oncolysis
- From bench to clinic
- From bench to clinic: the measles paradigm
- Clinical trials with oncolytic measles viruses
- Myeloma phase I clinical trial
- Remission of cancer after oncolytic virotherapy
- Clinical response to systemic MV-NIS
- SPECT/CT scans pre- and post- MV-NIS therapy
- Big picture: new anticancer weapons
- Acknowledgment
Topics Covered
- Modified viruses as friends
- Most licensed vaccines are live-attenuated viruses
- Natural oncolytic properties of viruses
- Preferential replication, efficient tumor access
- Clinical trials with oncolytic viruses
- Licensed therapeutics
- Added oncolytic properties
- Targeting: entry and post-entry
- Arming strategies
- Shielding from neutralizing antibodies
- Monitoring oncolytic virus replication in tumors
- From bench to clinic: the measles paradigm
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Cattaneo, R. (2018, February 28). Viruses as anticancer weapons [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/IOFA7466.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Roberto Cattaneo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
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0:00
My name is Roberto Cattaneo and I work at the Mayo Clinic,
and I will speak today about using "Viruses as Anticancer Weapons".
0:12
Viruses are pathogens.
But since the very beginning of virology,
we are using them as friends,
we are making them into friends.
I will begin by introducing viruses as
effective vaccines and then go on discussing the new anticancer weapons.
0:32
Let me first introduce smallpox which is a dangerous virus,
has killed more than 300 million humans over historic times.
No question, this is a virus which is an enemy.
Smallpox has been eradicated through a campaign started in 1967,
50 years ago, and based on an animal virus which has
been used as a vaccine for the first time by Dr. Jenner about 200 years ago.
And based on this virus and thanks to a campaign by the World Health Organization,
smallpox is eradicated since now more than 40 years.
Other viruses which have killed humans include measles,
which has killed about 200 million children over historic times,
and the Spanish flu influenza,
which has killed more than 50 million people over only one year.
While all of these remains,
but we have changed viruses and have made them into vaccines,
and now with additional changes,
we are making them into anticancer weapons.