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1. Introduction
2. The spectrum of hepatitis viruses
3. Pathologic events in chronic hepatitis C
4. Global distribution of HCV infection
5. Emergence of HCV-related liver cancer
6. Liver cancer rates in the U.S. by race and sex
7. Hepatitis C pathogenesis: cellular level
8. Hepatitis C pathogenesis: system level
9. Hepatitis C pathogenesis: host consequences
10. HCV model systems
11. Hepatitis C virus
12. Cis-acting RNA elements of HCV
13. HCV 5' RNA structure
14. Translation of HCV genome vs. cellular mRNA
15. HCV IRES - 40S subunit binding affinity
16. IRES binding alters 40S conformation
17. Role of 3' terminal stem-loops of HCV RNA
18. HCV proteins hypothetical membrane topology
19. Hepatitis C virus structural proteins
20. Core protein
21. "F" protein
22. HCV envelope proteins
23. p7 protein: a target for drug discovery?
24. NS2 protein
25. NS2/3 proteinase
26. NS3 protein
27. NS3/4A proteinase
28. NS3/4A processing of nonstructural proteins
29. NS3 helicase/NTPase
30. Bifunctional NS3/4A proteinase/helicase
31. NS4A protein
32. NS4B protein
33. NS5A protein
34. NS5B RNA-dependent RNA polymerase
35. Hepatitis C virus life cycle
36. Polyprotein functions in the viral lifecycle
37. Subgenomic HCV replicon polyprotein
38. Dicistronic subgenomic HCV replicons
39. Subgenomic HCV replicon life cycle
40. HCV-infected Huh-7.5 hepatoma cells
41. Host factors - pathogenesis and viral replication
42. Cytoplasmic colocalization of Rb and NS5A
43. Viral persistence - central issue in hepatitis C
44. Possible mechanisms of HCV persistence
45. Virus-activated pathways lead to IFN synthesis
46. Suppression of HCV viremia with BILN 2061
47. Summary and conclusions

Topics Covered

• The spectrum of hepatitis viruses
• Global distribution of HCV infection
• Associated diseases
• Hepatitis C pathogenesis
• HCV model systems
• Replication of HCV RNA
• Hypothetical membrane topology of HCV proteins
• HCV structural proteins
• p7 protein
• Hepatitis C virus life cycle
• Polyprotein functions in the viral life cycle
• Subgenomic HCV replicon life cycle
• The central issue in hepatitis C is viral persistence
• Possible mechanisms of HCV persistence

Links

Series:

• Viruses and Viral Diseases

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Gastroenterology & Nephrology
• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 31, 2020

Financial Disclosures

• Prof. Stanley Lemon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.