Share these talks and lectures with your colleagues
Invite colleaguesWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at support@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support support@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support support@hstalks.com
We hope you have enjoyed this limited-length demo talk
This is a limited length demo talk; you may
login
or review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Protein folding and misfolding
- Amyloid fibrils: features
- Finding exciting applications for amyloid fibrils
- Graphene-amyloid composites
- Amyloid aerogel
- Amyloid fibrils from waste materials
- Amyloid fibril production
- Identification of β-sheet structures
- Haemoglobin
- Eye lenses: a source of crystallin proteins
- “Standard conditions”
- Fibrils from crystallin proteins
- Tweaking the conditions, alters the morphology
- Assembly of bigger structures
- Controlling morphology (insulin)
- Controlling length (insulin)
- Applications like a carbon nanotube
- A nanoscaffold for immobilised enzymes
- Attachment of enzymes to fibrils
- Active OPH immobilised onto the nanoscaffold
- Amyloid fibrils have OPH activity
- Covalent crosslinking may not be essential
- Amyloid fibrils + OPH, glutaraldehyde
- Thermostability of OPH is improved at 45°C
- Nanofibrils, with quantum dots
- Dual functionalisation
- Towards useful materials
- Proof of concept: amyloid fibrils in PVOH films
- Immobilisation of glucose oxidase
- Glucose oxidase remains active on nanoscaffold
- Fibrils as nanowires?
- Glucose oxidase
- Glucose sensing experiment
- Glucose sensing
- Stability to proteases
- Stability to solvents
- Cytotoxicity: Hec1a cell lines
- Conclusions
- Acknowledgements
Topics Covered
- Generating useful materials from proteins
- Amyloid fibrils from waste materials in a commercially scalable process
- Nanoscaffolds for enzyme immobilisation
- Templates for nanowires and biosensors
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Gerrard, J. (2017, December 31). Amyloid fibrils as functional nanomaterials [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2018, from https://hstalks.com/bs/3641/.Talk Information
Amyloid fibrils as functional nanomaterials
Published on December 31, 2017
39 min
Other Talks in the Series: Protein Folding, Aggregation and Design
Transcript
0:00
My name is Juliet Gerrard,
and I'm from the University of Auckland.
And today I'd like to tell you about amyloid fibrils as functional Nanomaterials.
You've heard something about amyloid fibrils
from other lectures in this series, but today,
rather than focus on their role in the body or in disease,
I'll be talking you through how you might think of them as
a useful material to use outside the body for a whole range of application.
So, as an outline of my talk,
0:30
I'll start up just to orient you and take you through what amyloid fibrils
are and how and why we want to make them.
And I'll just give you a quick taste of the sorts of
applications that are being developed for these materials worldwide.
Then I'll focus on our efforts in my lab to generate
amyloid fibrils from readily available sustainable sources.
And I'll give you a couple of examples of applications that we've worked on in
my lab that really exemplify the strengths of these materials.
First of all as a nanoscaffold for enzyme immobilisation and
then as a template for nanowires and biosensors.