C3 glomerulopathy

Published on November 30, 2017   33 min
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My name is Matthew Pickering and I am a Wellcome Trust Senior Fellow in Clinical Science based at the Centre for Complement and Inflammation Research at the Imperial College, London. And the subject of my talk is C3 glomerulopathy. C3 glomerulopathy is a term used to describe
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a group of kidney diseases characterized by abnormal amounts of complement C3 within the kidney. It is a new disease classification first proposed in this paper in 2010 written by myself, Dr. Fakhouri, Professor of renal medicine in Nantes, two renal pathologists, Laure-Helene Noel and Terence Cook and a complement biologist, Veronique Fremeaux-Bacchi. The talk will cover the definition of C3 glomerulopathy, its pathogenesis, lessons from animal models and therapeutic considerations. When I refer to published data, you will see the relevant references at the bottom of the slides. So, let us start with what is C3 glomerulopathy.