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1. Introduction
2. Marburg virus history
3. Ebola virus history
4. Known Ebola virus outbreaks
5. Information to family members of Ebola patients
6. Genes and gene products
7. Filovirus structure
8. Ebola virus entry
9. Structure of GP
10. Filovirus RNA synthesis
11. Ebola minigenome with GFP-CAT fusion
12. Ebola minigenome assay
13. VP40 late domains mediate viral budding
14. Ebola virus pathogenesis
15. The interferon system (1)
16. The interferon system (2)
17. delNS1 virus complementation assay
18. VP35 protein complements growth of delNS1 virus
19. IFN beta-reporter assay of interferon function
20. VP35 blocks SeV activation of ISRE-54 promoter
21. VP35 inhibits virus-induced IFN-beta expression
22. VP24 inhibits IFN alpha/beta-induced signaling?
23. EBOV inhibits PY-STAT1 nuclear accumulation
24. STAT1 nuclear import
25. VP24 interacts with karyopherin alpha 1
26. VP24 inhibits interaction of STAT1 with K-alpha-1
27. Ebola viruses must be adapted to be lethal in mice
28. Interferon-alpha/beta receptor knockout mice
29. Genetic changes during mouse adaptation
30. Growth in the presence of IFN alpha/beta
31. Vaccines
32. Vesicular stomatitis virus-based vaccine
33. Future directions

Topics Covered

• Filovirus history
• Filovirus genes, proteins and structure
• Filovirus replication cycle
• Evasion of interferon responses by filoviruses
• Filovirus vaccines

Links

Series:

• Viruses and Viral Diseases

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Dr. Christopher Basler has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.