• Overview of Molecular Chaperones
• 34 min
  1. History of the molecular chaperone concept: roles in assembly processes

  • Prof. Emeritus R. John Ellis
• 34 min
  2. Chaperone mechanisms in cellular protein folding

  • Prof. Dr. F. Ulrich Hartl
• Prokaryotic Molecular Chaperones
• 38 min
  3. Mechanistic aspects of chaperonin GroEL/ES function

  • Prof. Amnon Horovitz
• 99 min
  4. Structure and function of the ATP-dependent Clp chaperone/protease machines

  • Dr. Michael R. Maurizi
• 32 min
  5. The role of chaperones and Sec machinery in protein secretion

  • Prof. Koreaki Ito
• 44 min
  6. How can molecular chaperones repair damaged protein structures?

  • Prof. Pierre Goloubinoff
• 32 min
  7. Disulfide bond formation in vivo

  • Prof. James Bardwell
• Eukaryotic Molecular Chaperones
• 39 min
  8. Overview of eukaryotic molecular chaperones in the cytosol

  • Dr. Jason C. Young
• 36 min
  9. Chaperonin-containing TCP-1 (CCT), actin springs, and protein folding fluxes

  • Prof. Keith Willison
• 35 min
  10. The functions of the Hsp70 system

  • Prof. Jeffrey L. Brodsky
• 26 min
  11. Hsp90: a chaperone for protein kinases and hormone receptors

  • Dr. David Toft
• Role of Chaperones in Diseases
• 38 min
  12. The roles of molecular chaperones in bacterial infection

  • Prof. Tomoko Yamamoto
• 46 min
  13. Role of chaperonin-like proteins in Bardet-Biedl syndrome

  • Dr. Michel R. Leroux
• 53 min
  14. Roles for molecular chaperones in cystic fibrosis

  • Prof. Douglas M. Cyr
• 51 min
  15. Targeting cancer: designing drugs against Hsp90

  • Dr. Gabriela Chiosis
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  16. Overview of prokaryotic molecular chaperones

  • Prof. Walid A. Houry
• 47 min
  17. The biogenesis of E. coli inner membrane proteins

  • Dr. Joen Luirink
• 39 min
  18. Mechanism of chaperone action of small heat shock proteins

  • Prof. Elizabeth Vierling
• 22 min
  19. ClpB: a chaperone for protein disaggregation

  • Prof. Michal Zolkiewski
• 38 min
  20. The roles of chaperonins in bacteria

  • Dr. Peter Lund
• 44 min
  21. Towards a unifying mechanism for the Hsp70 chaperones

  • Prof. Pierre Goloubinoff
• 29 min
  22. Adaptor mediated activation of the Hsp100/ Clp protein ClpC controls general and regulatory proteolysis in Bacillus subtilis

  • Prof. Dr. Kursad Turgay
• 33 min
  23. Hsp31: a general stress protein of Escherichia coli

  • Prof. Francois Baneyx
• 46 min
  24. Hsp104: a specialized chaperone for protein disaggregation

  • Dr. John R. Glover
• 47 min
  25. Molecular chaperones and handling of abnormal proteins in neurodegenerative disorders

  • Prof. Michael Sherman
• 20 min
  26. The role of chaperones in Parkinson's disease

  • Dr. Konstanze F. Winklhofer

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Anticancer target: definition
3. Hsp90 - an ideal anti-cancer target?
4. Geldanamycin - discovery in phenotypic screen
5. Tumoricidal activity of ansamycins
6. Inhibition of Hsp90-pp60 complex formation
7. Hsp90-geldanamycin complex crystal structure
8. Geldanamycin blocks Hsp90 biological function
9. Mutant p53 requires functional Hsp90
10. Transformation-specific effects of Hsp90
11. Broad-spectrum effects of Hsp90
12. Hsp90 inhibition may affect many cancers
13. Hsp90 acts as a "buffer" of transformation
14. Are Hsp90 inhibitors a solution to cancer?
15. Tumor selectivity on Hsp90 inhibitors
16. Validation of Hsp90 as a target
17. Ansamycins
18. Improved formulations of 17-AAG (1)
19. Improved formulations of 17-AAG (2)
20. Pharmacodynamic markers
21. Radicicols
22. ADP inside Hsp90/kinase pocket
23. Purine-scaffold Hsp90 inhibitors (1)
24. PU3 mimics the biological effects of GM
25. Purine-scaffold Hsp90 inhibitors (2)
26. Pyrazole derivatives
27. Other Hsp90 inhibitors
28. Conclusions from small Hsp90 inhibitors use
29. Classical pharmacokinetic analysis relevance
30. Inhibition of Hsp90 - cytostatic or cytotoxic?
31. Limiting factors of anti-cancer potential (1)
32. Limiting factors of anti-cancer potential (2)
33. Limiting factors of anti-cancer potential (3)
34. Hsp90 inhibitors translation to other diseases
35. Concluding remarks

Topics Covered

• Heat shock protein 90 (Hsp90), a target in cancer
• Discovery of the first known Hsp90 inhibitor, geldanamycin
• Use of geldanamycin to understand the role of Hsp90 in malignant transformation
• Discovery of novel Hsp90 inhibitors
• Development and applications of Hsp90 inhibitors

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cancer
• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 28, 2025

Financial Disclosures

• Dr. Gabriela Chiosis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.