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Transport and delivery of neurotrophic peptides and proteins across the BBB
Published on January 31, 2017 34 min
A selection of talks on Neurology
Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
- University of Sydney, Australia
Brachial plexus and nerves of upper limb
- Prof. S. P. Banumathy
- Madurai Medical College, India
How are synapses affected by Alzheimer's disease?
- Dr. Mariana Vargas-Caballero
- University of Southampton, UK
Stroke rehabilitation: therapies and treatments
- Prof. Robert Teasell
- Western University, Canada
Hello, I am Dr. Weihong Pan. In this slide set, I will discuss "Transport and Delivery of Neurotrophic Peptides and Proteins across the BBB".
Here is the outline. The first part is about the blood-brain barrier, or BBB in short, to peptides and proteins with a discussion of flow-independent influx transport systems. The second part addresses influx transport of neurotrophic peptides and proteins. The third part will move to the biotechnology sector and the goals of CNS drug delivery. The last part will focus on physiological regulations, particularly those related to sleep and the circadian rhythms.
In part one, I will have a brief review of pertinent features of the BBB, discuss the dynamic context involving interstitial space, cerebrospinal fluid or CSF, and the cellular compartments. I will then summarize study methods including the classics and updates.
To formulate the image of a three-dimensional blood-brain barrier, let's first take a sample of 1 square millimeter of brain tissue. If it is from an adult human cerebral cortex, within the 1 square millimeter, there will be about 50,000 neurons and 300 million synapses. No neuron is more than 8 microns away from a microvessel, as well as glial cells. The density of microvessels is clearly seen from the vascular corrosion cast image, in the upper right circle. Each artery branches to arterioles, then capillary beds that has a vast surface area, and finally, they drain into venules and small veins. In the capillaries and the venules where blood flow is very slow and conducive to exchange of fluid components, that's where the BBB shows a unique structure that varies among species. In general, the microvessel wall lacks fenestration and is reinforced by tight junctions and adherent junction complexes. This greatly reduces vascular permeability and makes specific transport systems extremely important.