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1. Introduction
2. Talk outline
3. Hsp90
4. Molecular chaperones
5. Early studies on Hsp90/client interaction
6. Hsp90 client proteins
7. Hsp90 clients
8. Hsp90 biology
9. Chaperoning steroid receptors
10. Steroid receptor action
11. The assembly of Hsp90 complexes with PR
12. PR chaperoning cycle
13. The Hsp90 machine
14. In vitro approaches
15. 5-protein system
16. Time course of PR complex assembly
17. Loading Hsp90 and conformational change
18. Intermediate complex assembly
19. Steps promoting conformational change
20. Hsp90 structure
21. Conformational states
22. Hsp90 domains
23. Hsp90 domains - N terminal domain
24. A model of N domain with bound ADP
25. Hsp90 inhibitors
26. Hsp90 domains - M domain
27. Hsp90 domains - C terminal domain
28. E. coli Hsp90 in open conformation (1)
29. E. coli Hsp90 in open conformation (2)
30. Yeast Hsp90 in ATP-bound conformation (1)
31. Yeast Hsp90 in ATP-bound conformation (2)
32. Hsp90 structure: in the absence of ATP
33. Hsp90 structure: ATP-bound state
34. Hsp90 structure: additional conformational states
35. Do various clients have specific needs?
36. Checkpoint kinase 1 (Chk1)
37. 5-protein system: Cdc37 and CK3
38. Chk1 kinase activity
39. Chk1 vs. PR
40. Alternate pathways for different clients
41. Co-chaperones provide diversity to Hsp90
42. Hsp90 co-chaperones
43. Role of co-chaperones
44. Coordinating conformation and function of Hsp90
45. Recognizing specific client groups
46. Bringing an additional activity to Hsp90 complexes
47. Trafficking or other specialized functions
48. Co-chaperones are targets for inhibitor drugs
49. Co-chaperone binding
50. Mouse knockout studies
51. Some key questions
52. What is the big picture?
53. End of the talk
54. Bibliography (1)
55. Bibliography (2)
56. Bibliography (3)
57. Websites

Topics Covered

• Chaperoning steroid receptors; the Hsp90 chaperoning machine
• Hsp90 structure and function
• Chaperoning protein kinases and other Hsp90 clients

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Toft, D. (2007, October 1). Hsp90: a chaperone for protein kinases and hormone receptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/KRES2435.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. David Toft has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.