Pharmacometric approaches to optimize use of drugs and dialysis treatments in patients with chronic kidney disease

Published on December 4, 2014   30 min

Other Talks in the Series: The Kidney in Health and Disease

Other Talks in the Series: Topical Talks

0:00
This is a talk for the Henry Stewart Collection. I'm Marc Pfister, a trained nephrologist. I worked in Switzerland and in the US, in California at UCSF, before I joined a couple of pharmaceutical companies. And now I work as Chief Medical Officer for a global consulting company. The topic of this lecture is "Pharmacometric Approaches to Optimize Use of Drugs and Dialysis Treatments in Patients with Chronic Kidney Disease."
0:36
Before we go to a couple of case studies, I want to briefly review the concept of therapeutic window. The goal of every treatment in our patients is to improve, extend, save lives. So the goal is to optimize the dosing so that patients have maximum benefit and minimal risk for adverse events, safety events. To obtain that goal, we need to understand the exposure range, the concentration range for a given drug and treatment. And the goal is to have a maturity of patients with this exposure range so that, again, we can optimize benefits and minimize the risk for adverse events for these patients. And that range of target concentrations is called therapeutic window.
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Pharmacometric approaches to optimize use of drugs and dialysis treatments in patients with chronic kidney disease

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